Whole Genome 5′-Methylcytosine Level Quantification in Cirrhotic HCV-Infected Egyptian Patients with and without Hepatocellular Carcinoma
المؤلفون المشاركون
Awad, Ahmed M.
Ragab, Wafaa S.
Degheidy, Nourhan
Ooda, Said Ahmed
المصدر
International Journal of Genomics
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-10-05
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
DNA methylation is an epigenetic mechanism used by cells to control gene expression.
DNA methylation is a commonly used epigenetic signaling tool that can hold genes in the “off” position.
Chronic infection with hepatitis C virus (HCV) is considered a major risk for chronic liver impairment.
It is the most common leading cause of HCC.
The present work is aimed at studying whole genome 5′-methylcytosine levels in cirrhotic HCV-infected Egyptian patients.
In the present study, 120 Egyptian adults were included.
They were divided into two groups: group І (40 apparently healthy control subjects) and group ІІ (80 HCV-infected patients).
Furthermore, group II was subdivided into 2 subgroups according to the presence of HCC in HCV-infected subjects.
To all studied subjects, the level of 5-mC% was measured in peripheral blood.
In the present study, the median of 5′-methylcytosine% in the control group (group I) was 2.5, in the HCV group (group IIa) was 2.45, and in the HCC group (group II b) was 2.25.
A stepwise decrease in 5′-methylcytosine% from the control (group I) toward HCC (group IIb) was observed, taking into consideration that the stepwise global hypomethylation was not statistically significant (p=0.811).
There was a negative correlation between ALT and 5′-methylcytosine% (p=−0.029).
From this study, we can conclude that global DNA 5′-methylcytosine% does not differ in HCV-infected cirrhotic patients and HCC patients when compared to normal controls.
Consecutively, we had concluded that there is no impact of 5′-methylcytosine% on the development of liver cirrhosis or HCC.
Moreover, the negative correlation between 5′-methylcytosine% and serum ALT level denotes a trend of decrease in 5′-methylcytosine% with more liver damage.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Awad, Ahmed M.& Ragab, Wafaa S.& Degheidy, Nourhan& Ooda, Said Ahmed. 2020. Whole Genome 5′-Methylcytosine Level Quantification in Cirrhotic HCV-Infected Egyptian Patients with and without Hepatocellular Carcinoma. International Journal of Genomics،Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1171185
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Awad, Ahmed M.…[et al.]. Whole Genome 5′-Methylcytosine Level Quantification in Cirrhotic HCV-Infected Egyptian Patients with and without Hepatocellular Carcinoma. International Journal of Genomics No. 2020 (2020), pp.1-8.
https://search.emarefa.net/detail/BIM-1171185
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Awad, Ahmed M.& Ragab, Wafaa S.& Degheidy, Nourhan& Ooda, Said Ahmed. Whole Genome 5′-Methylcytosine Level Quantification in Cirrhotic HCV-Infected Egyptian Patients with and without Hepatocellular Carcinoma. International Journal of Genomics. 2020. Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1171185
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1171185
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر