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Meta-Analysis of the Association between Vitamin D Receptor Polymorphisms and the Risk of Autoimmune Thyroid Disease
المؤلفون المشاركون
المصدر
International Journal of Endocrinology
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-15، 15ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-03-22
دولة النشر
مصر
عدد الصفحات
15
التخصصات الرئيسية
الملخص EN
The association between vitamin D receptor (VDR) polymorphisms (rs731236, rs1544410, rs2228570, and rs7975232) and the risk of autoimmune thyroid disease (AITD) had been investigated in previous studies.
However, the results of these studies remained controversial.
Thus, a meta-analysis was performed to derive a more precise conclusion.
All related articles were systematically searched by PubMed, Embase, Google Scholar, and Chinese National Knowledge Infrastructure (CNKI).
The pooled odds ratios (ORs) with 95% confidence intervals (CIs) were calculated to assess the strength of association.
The overall results indicated that VDR rs731236 and rs2228570 polymorphisms were significantly associated with a reduced risk of AITD.
However, a stratification analysis based on clinical types showed that VDR rs731236 and rs2228570 polymorphisms were associated only with a reduced risk of HT.
A stratification analysis by ethnicity showed that VDR rs731236 polymorphism was significantly associated with a reduced risk of AITD in Asian and African populations.
VDR rs2228570 polymorphism was associated with a reduced risk of AITD in Asian populations.
VDR rs1544410 polymorphism was associated with a reduced risk of AITD in European and African populations, but with an increased risk of AITD in Asian populations.
VDR rs7975232 polymorphism was significantly associated with an increased risk of AITD in African populations.
In conclusion, the present study suggested that VDR rs731236, rs1544410, rs2228570, and rs7975232 polymorphisms were significantly associated with AITD risk.
However, more well-designed studies should be performed to verify the current results.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Gao, Xue-Ren& Yu, Yong-Guo. 2018. Meta-Analysis of the Association between Vitamin D Receptor Polymorphisms and the Risk of Autoimmune Thyroid Disease. International Journal of Endocrinology،Vol. 2018, no. 2018, pp.1-15.
https://search.emarefa.net/detail/BIM-1171194
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Gao, Xue-Ren& Yu, Yong-Guo. Meta-Analysis of the Association between Vitamin D Receptor Polymorphisms and the Risk of Autoimmune Thyroid Disease. International Journal of Endocrinology No. 2018 (2018), pp.1-15.
https://search.emarefa.net/detail/BIM-1171194
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Gao, Xue-Ren& Yu, Yong-Guo. Meta-Analysis of the Association between Vitamin D Receptor Polymorphisms and the Risk of Autoimmune Thyroid Disease. International Journal of Endocrinology. 2018. Vol. 2018, no. 2018, pp.1-15.
https://search.emarefa.net/detail/BIM-1171194
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1171194
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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