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Metabonomic-Transcriptome Integration Analysis on Osteoarthritis and Rheumatoid Arthritis
المؤلفون المشاركون
Cao, Yuelong
Zheng, Yuxin
Zhan, Hongsheng
Pang, Jian
Gao, Ningyang
Ding, Li
Shi, Yinyu
المصدر
International Journal of Genomics
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-01-02
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Purpose.
This study is aimed at exploring the potential metabolite/gene biomarkers, as well as the differences between the molecular mechanisms, of osteoarthritis (OA) and rheumatoid arthritis (RA).
Methods.
Transcriptome dataset GSE100786 was downloaded to explore the differentially expressed genes (DEGs) between OA samples and RA samples.
Meanwhile, metabolomic dataset MTBLS564 was downloaded and preprocessed to obtain metabolites.
Then, the principal component analysis (PCA) and linear models were used to reveal DEG-metabolite relations.
Finally, metabolic pathway enrichment analysis was performed to investigate the differences between the molecular mechanisms of OA and RA.
Results.
A total of 976 DEGs and 171 metabolites were explored between OA samples and RA samples.
The PCA and linear module analysis investigated 186 DEG-metabolite interactions including Glycogenin 1- (GYG1-) asparagine_54, hedgehog acyltransferase- (HHAT-) glucose_70, and TNF receptor-associated factor 3- (TRAF3-) acetoacetate_35.
Finally, the KEGG pathway analysis showed that these metabolites were mainly enriched in pathways like gap junction, phagosome, NF-kappa B, and IL-17 pathway.
Conclusions.
Genes such as HHAT, GYG1, and TRAF3, as well as metabolites including glucose, asparagine, and acetoacetate, might be implicated in the pathogenesis of OA and RA.
Metabolites like ethanol and tyrosine might participate differentially in OA and RA progression via the gap junction pathway and phagosome pathway, respectively.
TRAF3-acetoacetate interaction may be involved in regulating inflammation in OA and RA by the NF-kappa B and IL-17 pathway.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Gao, Ningyang& Ding, Li& Pang, Jian& Zheng, Yuxin& Cao, Yuelong& Zhan, Hongsheng…[et al.]. 2020. Metabonomic-Transcriptome Integration Analysis on Osteoarthritis and Rheumatoid Arthritis. International Journal of Genomics،Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1171268
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Gao, Ningyang…[et al.]. Metabonomic-Transcriptome Integration Analysis on Osteoarthritis and Rheumatoid Arthritis. International Journal of Genomics No. 2020 (2020), pp.1-9.
https://search.emarefa.net/detail/BIM-1171268
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Gao, Ningyang& Ding, Li& Pang, Jian& Zheng, Yuxin& Cao, Yuelong& Zhan, Hongsheng…[et al.]. Metabonomic-Transcriptome Integration Analysis on Osteoarthritis and Rheumatoid Arthritis. International Journal of Genomics. 2020. Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1171268
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1171268
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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