A Pooling Genome-Wide Association Study Identifies Susceptibility Loci and Signaling Pathways of Immune Thrombocytopenia in Chinese Han Population
المؤلفون المشاركون
Lin, Jin
Li, Jing
Huang, Bo
Liu, Jing
Xu, Yan-Mei
Wang, Xiao-Zhong
Yang, Wentao
Tang, Xiaoli
Zhang, Jing
Yang, Weiming
Li, Shuqi
Sun, Fan
Deng, Libin
المصدر
International Journal of Genomics
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-03-11
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Immune thrombocytopenia (ITP) is an acquired bleeding disease due to immune-mediated destruction of antilogous platelets and ineffective thrombopoiesis.
Although the etiology of ITP remains unknown, genetic variants are thought to predispose individuals to the disease.
Several candidate gene analyses have identified several loci that increased ITP susceptibility, but no systematic genetic analysis on a genome-wide scope.
To extend the genetic evidence and to identify novel candidates of ITP, we performed a pooling genome-wide association study (GWAS) by IlluminaHumanOmniZhongHua-8 combining pathway analysis in 200 ITP cases and 200 controls from Chinese Han population (CHP).
The results revealed that 4 novel loci (rs117503120, rs5998634, rs4483616, and rs16866133) were strongly associated with ITP (P<1.0×10−7).
Expect for rs4483616, other three loci were validated by the TaqMan probe genotyping assay (P<0.05) in another cohort including 250 ITP cases and 250 controls.
And rs5998634 T allele was more sensitive to glucocorticoids for ITP patients (χ2=7.30, P<0.05).
Moreover, we identified three overrepresented signaling pathways including the neuroactive ligand-receptor interaction, pathways in cancer, and the JAK-STAT pathway, which involved in the etiology of ITP.
In conclusion, our results revealed four novel loci and three pathways related to ITP and provided new clues to explore the pathogenesis of ITP.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Xu, Yan-Mei& Li, Jing& Yang, Wentao& Tang, Xiaoli& Huang, Bo& Liu, Jing…[et al.]. 2020. A Pooling Genome-Wide Association Study Identifies Susceptibility Loci and Signaling Pathways of Immune Thrombocytopenia in Chinese Han Population. International Journal of Genomics،Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1171314
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Xu, Yan-Mei…[et al.]. A Pooling Genome-Wide Association Study Identifies Susceptibility Loci and Signaling Pathways of Immune Thrombocytopenia in Chinese Han Population. International Journal of Genomics No. 2020 (2020), pp.1-9.
https://search.emarefa.net/detail/BIM-1171314
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Xu, Yan-Mei& Li, Jing& Yang, Wentao& Tang, Xiaoli& Huang, Bo& Liu, Jing…[et al.]. A Pooling Genome-Wide Association Study Identifies Susceptibility Loci and Signaling Pathways of Immune Thrombocytopenia in Chinese Han Population. International Journal of Genomics. 2020. Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1171314
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1171314
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر