Synthesis and Experimental Validation of New PDI Inhibitors with Antiproliferative Activity
المؤلفون المشاركون
Badolato, Mariateresa
Carullo, Gabriele
Aiello, Francesca
Garofalo, Antonio
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-06-15
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Protein disulfide isomerase (PDI) is a member of the thioredoxin superfamily of redox enzymes.
PDI is a multifunctional protein that catalyzes disulfide bond formation, cleavage, and rearrangement in unfolded or misfolded proteins and functions as a chaperone in the endoplasmic reticulum.
Besides acting as a protein folding catalyst, several evidences have suggested that PDI can bind small molecules containing, for example, a phenolic structure, which includes the estrogenic one.
Increasing studies indicate that PDI is involved in both physiology and pathophysiology of cells and tissues and is involved in the survival and proliferation of different cancers.
Propionic acid carbamoyl methyl amides (PACMAs) showed anticancer activity in human ovarian cancer, both in vitro and in vivo, by inhibiting PDI.
The inhibition of PDI’s activity may have a therapeutic role, in various diseases, including cancer.
In the present study, we designed and synthesized a diversified small library of compounds with the aim of identifying a new class of PDI inhibitors.
Most of synthesized compounds showed a good inhibitory potency against PDI and particularly 4-methyl substituted 2,6-di-tert-butylphenol derivatives (8–10) presented an antiproliferative activity in a wide panel of human cancer cell lines, including ovarian ones.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Badolato, Mariateresa& Carullo, Gabriele& Aiello, Francesca& Garofalo, Antonio. 2017. Synthesis and Experimental Validation of New PDI Inhibitors with Antiproliferative Activity. Journal of Chemistry،Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1171529
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Badolato, Mariateresa…[et al.]. Synthesis and Experimental Validation of New PDI Inhibitors with Antiproliferative Activity. Journal of Chemistry No. 2017 (2017), pp.1-9.
https://search.emarefa.net/detail/BIM-1171529
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Badolato, Mariateresa& Carullo, Gabriele& Aiello, Francesca& Garofalo, Antonio. Synthesis and Experimental Validation of New PDI Inhibitors with Antiproliferative Activity. Journal of Chemistry. 2017. Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1171529
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1171529
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر