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Hepatic Steatosis Index in Acromegaly: Correlation with Insulin Resistance Regardless of the Disease Control
المؤلفون المشاركون
Giordano, Carla
Ciresi, Alessandro
Guarnotta, Valentina
Campo, Daniela
المصدر
International Journal of Endocrinology
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-12-19
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Objective.
In acromegaly, both lipotoxicity secondary to GH excess and insulin resistance have a significant impact on the liver.
Ultrasonography has shown poor sensitivity in detecting hepatic steatosis and noninvasive methods have been proposed.
We evaluated the hepatic steatosis index (HSI), a validated surrogate index of hepatic steatosis, and we correlated it with disease activity and insulin resistance.
Design.
Thirty-one patients with newly diagnosed acromegaly were studied at diagnosis and after 12 months of treatment with somatostatin receptor ligands.
Methods.
Glucose and insulin levels, surrogate estimates of insulin sensitivity, and hepatic steatosis through ultrasonography and HSI were evaluated.
Results.
At diagnosis, ultrasonography documented steatosis in 19 patients (61.2%) while 26 (83.8%) showed high HSI.
After 12 months, both GH (p=0.033) and IGF-1 (p<0.001) significantly decreased and, overall, 58% of patients were classified as controlled.
Ultrasonography documented steatosis in all the same initial 19 patients, while only 14 patients (45.1%) showed high HSI (p<0.001).
A significant reduction in HOMA-IR (p=0.002) and HSI (p<0.001) and increased ISI Matsuda (p<0.001), was documented.
The change of HSI from baseline to 12 months was found to be directly correlated with the change of ISI (Rho -0.611; p=0.004) while no correlation was found with the change of GH or IGF-1 levels and other parameters.
Conclusions.
In acromegaly, HSI is mainly related with insulin resistance and the reduction of GH and IGF-1 levels, and above all the improvement in insulin sensitivity leads to an improvement of this surrogate index of hepatic steatosis.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ciresi, Alessandro& Guarnotta, Valentina& Campo, Daniela& Giordano, Carla. 2018. Hepatic Steatosis Index in Acromegaly: Correlation with Insulin Resistance Regardless of the Disease Control. International Journal of Endocrinology،Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1171550
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ciresi, Alessandro…[et al.]. Hepatic Steatosis Index in Acromegaly: Correlation with Insulin Resistance Regardless of the Disease Control. International Journal of Endocrinology No. 2018 (2018), pp.1-7.
https://search.emarefa.net/detail/BIM-1171550
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ciresi, Alessandro& Guarnotta, Valentina& Campo, Daniela& Giordano, Carla. Hepatic Steatosis Index in Acromegaly: Correlation with Insulin Resistance Regardless of the Disease Control. International Journal of Endocrinology. 2018. Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1171550
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1171550
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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