Adiponectin and Leptin at Early Pregnancy: Association to Actual Glucose Disposal and Risk for GDM—A Prospective Cohort Study
المؤلفون المشاركون
Luger, Anton
Pacini, Giovanni
Göbl, Christian
Bozkurt, Latife
Kautzky-Willer, Alexandra
Baumgartner-Parzer, Sabina M.
المصدر
International Journal of Endocrinology
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-07-15
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Aim.
There is scarce information on associations of adipokines, and concurrent glucose disposal during early pregnancy as performance of oral glucose tolerance is uncommon before 24th gestational week.
We sought to examine associations of leptin and adiponectin to insulin sensitivity already at early pregnancy before recommended screening for GDM and to describe trajectories of adiponectin in relation to GDM status.
Methods.
216 pregnant women were prospectively included at 16th (IQR: 14–18) gestational week (GW) for fasting adiponectin and leptin with subsequent OGTT testing for evaluation of insulin sensitivity and β-cell function.
Follow-ups of adiponectin were performed at further four visits until 8–12 weeks after delivery.
Results.
In early pregnancy, differences in adiponectin and leptin were significant between GDM women (n=82) and controls (n=134), whereby those with early GDM (<21st week, n=49) showed more distinguishing levels (adiponectin: 8.5 ± 3.8 versus 10.4 ± 4.4 μg/ml, p=0.004; leptin 93.4 ± 38.5 versus 78.0 ± 39.2 μg/ml, p=0.005).
Both adipokines were significantly associated with insulin sensitivity and β-cell function.
Their attribution for GDM prediction was moderate to fair and more enhanced in early GDM.
Trajectories of adiponectin remained constantly lower in GDM women, whereas dynamics in controls showed initially increased concentrations with decreasing tendency until 3rd trimester.
After delivery, low adiponectin was associated with glucose dysregulation.
Conclusion.
Associations of adiponectin and leptin with features of deteriorated glucose metabolism at early gestation may be indicative for the endocrine involvement of adipose tissue in the manifestation of GDM and thus predictive for later impairments in metabolic flexibility in women at risk.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Bozkurt, Latife& Göbl, Christian& Baumgartner-Parzer, Sabina M.& Luger, Anton& Pacini, Giovanni& Kautzky-Willer, Alexandra. 2018. Adiponectin and Leptin at Early Pregnancy: Association to Actual Glucose Disposal and Risk for GDM—A Prospective Cohort Study. International Journal of Endocrinology،Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1171553
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Bozkurt, Latife…[et al.]. Adiponectin and Leptin at Early Pregnancy: Association to Actual Glucose Disposal and Risk for GDM—A Prospective Cohort Study. International Journal of Endocrinology No. 2018 (2018), pp.1-8.
https://search.emarefa.net/detail/BIM-1171553
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Bozkurt, Latife& Göbl, Christian& Baumgartner-Parzer, Sabina M.& Luger, Anton& Pacini, Giovanni& Kautzky-Willer, Alexandra. Adiponectin and Leptin at Early Pregnancy: Association to Actual Glucose Disposal and Risk for GDM—A Prospective Cohort Study. International Journal of Endocrinology. 2018. Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1171553
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1171553
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر