High-Serum Angiopoietin-Like Protein 3 Levels Associated with Cardiovascular Outcome in Patients with Coronary Artery Disease

المؤلفون المشاركون

Wang, Ji-Hung
Chen, Ming-Chun
Lee, Chung-Jen
Hsu, Bang-Gee

المصدر

International Journal of Hypertension

العدد

المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-7، 7ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2020-03-27

دولة النشر

مصر

عدد الصفحات

7

التخصصات الرئيسية

الأمراض
الطب البشري

الملخص EN

Background.

Angiopoietin-like protein 3 (ANGPTL3) plays a pivotal role in lipid metabolism and angiogenesis, and there is growing interest regarding the association between ANGPTL3 and coronary artery disease (CAD).

This study aims to investigate whether ANGPTL3 levels can be used to predict the future occurrence of major adverse cardiovascular events (MACEs) in patients with CAD.

Methods.

Overall, 90 patients with CAD were enrolled between January and December 2012.

The study’s primary endpoint was incidence of MACEs.

Patient follow-up was completed on June 30, 2017.

Results.

Following a median follow-up period of 54 months, 33 MACEs had occurred.

Patients reporting MACEs had lower statin use (P=0.022) and higher serum C-reactive protein (P<0.001) and serum ANGPTL3 (P<0.001) levels than those without MACEs.

Kaplan–Meier analysis revealed higher cumulative incidence of CV events in the high ANGPTL3 group (median ANGPTL3 level ≥ 222.37 ng/mL) than in the low ANGPTL3 group (log-rank P=0.046).

Multivariable Cox regression analysis demonstrated that ANGPTL3 levels were independently associated with MACEs in patients with CAD (hazard ratio: 1.003; 95% confidence interval: 1.000–1.005; P=0.026) after adjusted for age, gender, and body mass index, classical risk factors, and potential confounders.

Conclusions.

Serum ANGPTL3 levels could serve as a biomarker for future occurrence of MACEs in patients with CAD.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Chen, Ming-Chun& Hsu, Bang-Gee& Lee, Chung-Jen& Wang, Ji-Hung. 2020. High-Serum Angiopoietin-Like Protein 3 Levels Associated with Cardiovascular Outcome in Patients with Coronary Artery Disease. International Journal of Hypertension،Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1171595

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Chen, Ming-Chun…[et al.]. High-Serum Angiopoietin-Like Protein 3 Levels Associated with Cardiovascular Outcome in Patients with Coronary Artery Disease. International Journal of Hypertension No. 2020 (2020), pp.1-7.
https://search.emarefa.net/detail/BIM-1171595

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Chen, Ming-Chun& Hsu, Bang-Gee& Lee, Chung-Jen& Wang, Ji-Hung. High-Serum Angiopoietin-Like Protein 3 Levels Associated with Cardiovascular Outcome in Patients with Coronary Artery Disease. International Journal of Hypertension. 2020. Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1171595

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-1171595