Genetic Predisposition and Salt Sensitivity in a Chinese Han Population: The EpiSS Study
المؤلفون المشاركون
Liu, Kuo
Xi, Bo
Liu, Zheng
Qi, Han
Liu, Bin
Zhang, Jie
Cao, Han
Yan, Yuxiang
Zhao, Min
He, Yan
Zhang, Ling
المصدر
International Journal of Hypertension
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-02-17
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Objectives.
Genome-wide association studies and candidate gene studies have found many single nucleotide polymorphisms (SNPs) that affect salt sensitivity (SS).
We constructed a polygenic risk score (PRS) to estimate the joint effect of these SNPs on SS.
Methods.
We recruited 762 Chinese participants into the study.
An unweighted PRS was constructed using 42 known genetic risk variants associated with SS or salt sensitivity blood pressure.
A modified Sullivan’s acute oral saline load and diuresis shrinkage test was used to detect salt sensitivity.
Logistic regression was used to estimate the joint effect of the SNPs on SS both overall and after stratification by hypertension.
Results.
The mean age of the participants was 57.1 years, and most of them were female (77.4%).
The prevalence of SS was 28.7%.
Both the continuous PRS and PRS tertiles were significantly associated with the risk of SS and a BP increase of more than 5 mmHg during acute salt loading but were not associated with a BP decrease of more than 10 mmHg during the diuresis shrinkage process.
In the normotensive group, participants with PRSs in the middle and top tertiles had a more than twofold increased risk of SS (OR = 2.18, 95% CI: 1.15–4.12, P=0.016, and OR = 2.28, 95% CI: 1.19–4.38, P=0.013, respectively) compared with participants with PRSs in the first tertile.
In the normotensive group, participants with PRSs in the middle tertile (OR = 1.94, 95% CI: 1.01–3.71, P=0.046) and top tertile (OR = 2.30, 95% CI: 1.19–4.44, P=0.013) had an increased risk of a greater than 5 mmHg increase in BP during acute salt loading than those with PRSs in the first tertile.
In the hypertension group, neither the continuous PRS nor PRS tertile was significantly associated with the risk of SS.
Conclusion.
The 42 investigated SNPs were jointly and significantly associated with SS, especially in the normotensive Chinese population.
These findings may provide genetic evidence for identifying target populations that would benefit from salt restriction policies.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Liu, Kuo& Xi, Bo& Liu, Zheng& Qi, Han& Liu, Bin& Zhang, Jie…[et al.]. 2020. Genetic Predisposition and Salt Sensitivity in a Chinese Han Population: The EpiSS Study. International Journal of Hypertension،Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1171614
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Liu, Kuo…[et al.]. Genetic Predisposition and Salt Sensitivity in a Chinese Han Population: The EpiSS Study. International Journal of Hypertension No. 2020 (2020), pp.1-8.
https://search.emarefa.net/detail/BIM-1171614
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Liu, Kuo& Xi, Bo& Liu, Zheng& Qi, Han& Liu, Bin& Zhang, Jie…[et al.]. Genetic Predisposition and Salt Sensitivity in a Chinese Han Population: The EpiSS Study. International Journal of Hypertension. 2020. Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1171614
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1171614
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر