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Nafion®-Containing Solid Lipid Nanoparticles as a Tool for Anticancer Pt Delivery: Preliminary Studies
المؤلفون المشاركون
Sguizzato, Maddalena
Esposito, Elisabetta
Drechsler, Marcus
Gallerani, Eleonora
Gavioli, Riccardo
Carducci, Federica
Cortesi, Rita
Bergamini, Paola
Mariani, P.
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-03-23
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Preliminary studies of nanoparticles based on the perfluorosulfonic acid resin Nafion have been carried out with the aim of establishing an ionic connection with the protonable phosphine 1,3,5-triaza-7-phosphaadamantane (PTA), suitable for the coordination of platinum.
Nafion-containing nanoparticles (NAF) were produced by homogenization followed by ultrasonication method.
After production, NAF were characterized in terms of size, morphology, and in vitro cytotoxicity.
The PCS studies showed that the Z-average mean diameter was around 250 nm.
Moreover, the polydispersity index showed a monodimensional distribution of nanoparticles.
Cryo-TEM analysis showed a uniform and homogenous population of particles, characterized by the presence of both ovoidal and needle-like structures.
To evaluate the in vitro cytotoxicity, NAF were tested on human cancer cell lines K562 and A2780.
No cytotoxic effect was found on both cell lines.
By 13P-NMR measures, it is here proved that the strongly acidic sulfonic groups of Nafion-containing nanoparticles (NAF) can act as protonating agents for PTA.
The protonation occurs selectively at nitrogen; hence protonated PTA maintains its ability to coordinate platinum via its phosphorus atom.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Sguizzato, Maddalena& Esposito, Elisabetta& Drechsler, Marcus& Gallerani, Eleonora& Gavioli, Riccardo& Mariani, P.…[et al.]. 2017. Nafion®-Containing Solid Lipid Nanoparticles as a Tool for Anticancer Pt Delivery: Preliminary Studies. Journal of Chemistry،Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1171650
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Sguizzato, Maddalena…[et al.]. Nafion®-Containing Solid Lipid Nanoparticles as a Tool for Anticancer Pt Delivery: Preliminary Studies. Journal of Chemistry No. 2017 (2017), pp.1-6.
https://search.emarefa.net/detail/BIM-1171650
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Sguizzato, Maddalena& Esposito, Elisabetta& Drechsler, Marcus& Gallerani, Eleonora& Gavioli, Riccardo& Mariani, P.…[et al.]. Nafion®-Containing Solid Lipid Nanoparticles as a Tool for Anticancer Pt Delivery: Preliminary Studies. Journal of Chemistry. 2017. Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1171650
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1171650
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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