Synthesis and Biological Evaluation of Novel Jatrorrhizine Derivatives with Amino Groups Linked at the 3-Position as Inhibitors of Acetylcholinesterase
المؤلفون المشاركون
Jiang, Xiaofei
Zhang, Nengling
Xiong, Nanqian
Liu, Yi
Cao, Jianfeng
Qiu, Shengxiang
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-12-13
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Jatrorrhizine was considered as one of the active constituents of Coptis chinensis Franch.
Herein, jatrorrhizine derivatives with substituted amino groups linked at the 3-position were designed, synthesized, and biologically evaluated as inhibitors of acetylcholinesterase.
Jatrorrhizine derivatives inhibited the activity of acetylcholinesterase (AChE) to a greater extent than the lead compound jatrorrhizine.
All these jatrorrhizine derivatives were proved to be potent inhibitors of acetylcholinesterase (AChE) with submicromolar IC50 values, but less sensitive to butyrylcholinesterase (BuChE), which suggests that these jatrorrhizine derivatives are selective for AChE/BuChE.
Compound 3g gave the most potent inhibitor activity for AChE (IC50 = 0.301 μM), which is greater than the lead compound jatrorrhizine.
All these results demonstrated that these jatrorrhizine derivatives are potential inhibitors for AChE.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Jiang, Xiaofei& Zhang, Nengling& Xiong, Nanqian& Liu, Yi& Cao, Jianfeng& Qiu, Shengxiang. 2017. Synthesis and Biological Evaluation of Novel Jatrorrhizine Derivatives with Amino Groups Linked at the 3-Position as Inhibitors of Acetylcholinesterase. Journal of Chemistry،Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1171659
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Jiang, Xiaofei…[et al.]. Synthesis and Biological Evaluation of Novel Jatrorrhizine Derivatives with Amino Groups Linked at the 3-Position as Inhibitors of Acetylcholinesterase. Journal of Chemistry No. 2017 (2017), pp.1-6.
https://search.emarefa.net/detail/BIM-1171659
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Jiang, Xiaofei& Zhang, Nengling& Xiong, Nanqian& Liu, Yi& Cao, Jianfeng& Qiu, Shengxiang. Synthesis and Biological Evaluation of Novel Jatrorrhizine Derivatives with Amino Groups Linked at the 3-Position as Inhibitors of Acetylcholinesterase. Journal of Chemistry. 2017. Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1171659
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1171659
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر