Efficacy of Diltiazem for the Control of Blood Pressure in Puerperal Patients with Severe Preeclampsia: A Randomized, Single-Blind, Controlled Trial
المؤلفون المشاركون
Vargas-De-León, Cruz
Arias-Hernández, Gilberto
Calzada-Mendoza, Claudia C
Ocharan-Hernández, María Esther
المصدر
International Journal of Hypertension
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-07-25
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Background.
Postpartum preeclampsia is a serious disease related to high blood pressure that occurs commonly within the first six days after delivery.
Objective.
To evaluate if diltiazem improves blood pressure parameters in early puerperium patients with severe preeclampsia.
Methodology.
A randomized, single-blind longitudinal clinical trial of 42 puerperal patients with severe preeclampsia was carried out.
Patients were randomized into two groups: the experimental group (n = 21) received diltiazem (60 mg) and the control group (n = 21) received nifedipine (10 mg).
Both drugs were orally administered every 8 hours.
Systolic, diastolic, and mean blood pressures as well as the heart rate were recorded and analyzed (two-way repeated measures ANOVA) at baseline and after 6, 12, 18, 24, 30, 36, 42, and 48 hours.
Primary outcome measures were all the aforementioned blood pressure parameters.
Secondary outcome measures included the number of hypertension and hypotension episodes along with the length of stay in the intensive care unit.
Results.
No statistical differences were found between groups (diltiazem vs.
nifedipine) regarding basal blood pressure parameters.
Interarm differences in blood pressure (systolic, diastolic, and mean) and heart rate were statistically significant between treatment groups from 6 to 48 hours.
Patients in the diltiazem group had lower blood pressure levels than patients in the nifedipine group.
Significantly, patients who received diltiazem had fewer hypertension and hypotension episodes and stayed fewer days in the intensive care unit than those treated with nifedipine.
Conclusions.
Diltiazem controlled arterial hypertension in a more effective and uniform manner in patients under study than nifedipine.
Patients treated with diltiazem had fewer collateral effects and spent less time in the hospital.
This trial is registered with NCT04222855.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Arias-Hernández, Gilberto& Vargas-De-León, Cruz& Calzada-Mendoza, Claudia C& Ocharan-Hernández, María Esther. 2020. Efficacy of Diltiazem for the Control of Blood Pressure in Puerperal Patients with Severe Preeclampsia: A Randomized, Single-Blind, Controlled Trial. International Journal of Hypertension،Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1171671
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Arias-Hernández, Gilberto…[et al.]. Efficacy of Diltiazem for the Control of Blood Pressure in Puerperal Patients with Severe Preeclampsia: A Randomized, Single-Blind, Controlled Trial. International Journal of Hypertension No. 2020 (2020), pp.1-8.
https://search.emarefa.net/detail/BIM-1171671
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Arias-Hernández, Gilberto& Vargas-De-León, Cruz& Calzada-Mendoza, Claudia C& Ocharan-Hernández, María Esther. Efficacy of Diltiazem for the Control of Blood Pressure in Puerperal Patients with Severe Preeclampsia: A Randomized, Single-Blind, Controlled Trial. International Journal of Hypertension. 2020. Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1171671
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1171671
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر