Cardiometabolic Changes in Different Gonadal Female States Caused by Mild Hyperuricemia and Exposure to a High-Fructose Diet
المؤلفون المشاركون
Soutelo, Jimena
Alejandra Samaniego, Yanina
Cecilia Fornari, María
Reyes Toso, Carlos
Juan Ponzo, Osvaldo
المصدر
International Journal of Endocrinology
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-08-28
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Background.
The objective of this study is to observe if mild hyperuricemia and a high-fructose diet influence the cardiovascular and metabolic systems in hypogonadic female Wistar rats compared to normogonadic female rats.
Methods.
Fifty-six (56) adult female Wistar rats were used in the present work.
Animals were divided into two groups: normogonadic (NGN) and hypogonadic (HGN).
These groups were also divided into four subgroups in accordance with the treatment: control with only water (C), fructose (F), oxonic acid (OA), and fructose + oxonic acid (FOA).
Lipid profile, glycemia, uric acid, and creatinine determinations were assessed.
Cardiovascular changes were evaluated by measuring blood pressure, myocyte volume, fibrosis, and intima-media aortic thickness.
Results.
HGN rats had higher levels of total cholesterol (TC) (p<0.01) and noHDLc (p<0.01), in addition to higher levels of uric acid (p<0.05).
The OA group significantly increased myocyte volume (p<0.0001) and the percentage of fibrosis as well as the group receiving FOA (p<0.001) in both gonadal conditions, being greater in the HGN group.
Hypogonadic animals presented a worse lipid profile.
Conclusion.
Mild hyperuricemia produces hypertension together with changes in the cardiac hypertrophy, fibrosis, and increased thickness of the intima media in hypogonadic rats fed high-fructose diet.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Soutelo, Jimena& Alejandra Samaniego, Yanina& Cecilia Fornari, María& Reyes Toso, Carlos& Juan Ponzo, Osvaldo. 2018. Cardiometabolic Changes in Different Gonadal Female States Caused by Mild Hyperuricemia and Exposure to a High-Fructose Diet. International Journal of Endocrinology،Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1171681
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Soutelo, Jimena…[et al.]. Cardiometabolic Changes in Different Gonadal Female States Caused by Mild Hyperuricemia and Exposure to a High-Fructose Diet. International Journal of Endocrinology No. 2018 (2018), pp.1-9.
https://search.emarefa.net/detail/BIM-1171681
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Soutelo, Jimena& Alejandra Samaniego, Yanina& Cecilia Fornari, María& Reyes Toso, Carlos& Juan Ponzo, Osvaldo. Cardiometabolic Changes in Different Gonadal Female States Caused by Mild Hyperuricemia and Exposure to a High-Fructose Diet. International Journal of Endocrinology. 2018. Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1171681
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1171681
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر