High Neutrophil-to-Lymphocyte Ratio Predicts Hemorrhagic Transformation in Acute Ischemic Stroke Patients Treated with Intravenous Thrombolysis
المؤلفون المشاركون
Liu, Yong-Lin
Lu, Jie-Kai
Yin, Han-Peng
Xia, Pei-Shan
Qiu, Dong-Hai
Liang, Man-Qiu
Qu, Jian-Feng
Chen, Yang-Kun
المصدر
International Journal of Hypertension
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-02-28
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Background.
The relationship between the neutrophil-to-lymphocyte ratio (NLR) and hemorrhagic transformation (HT) in acute ischemic stroke (AIS) treated with intravenous thrombolysis (IVT) remains unclear.
This study assessed whether high NLR is associated with HT in this population.
Methods.
Data were prospectively collected for continuous patients with AIS treated with IVT and retrospectively analyzed.
Clinical variables included age, sex, vascular risk factors, National Institutes of Health Stroke Scale (NIHSS) score, onset-to-treatment time, and initial hematologic and neuroimaging findings.
HT was confirmed by imaging performed within 3 days after IVT.
Symptomatic HT (sHT) was defined as NIHSS score increased by 4 points compared with that on admission according to previously published criteria.
The NLR value was based on the blood examination before IVT, and high NLR was defined as ≥75th percentile.
Results.
The study included 285 patients (201 (70.5%) males, the mean age was 62.3 years (range 29–89)).
Seventy-two (25.3%) patients presented with HT, including three (1.1%) with sHT.
The median NLR was 2.700 (1.820–4.255, interquartile range).
Seventy-one (24.9%) patients had a high NLR (≥4.255) on admission.
Univariate analysis indicated that patients with HT had higher NIHSS scores (P<0.001), systolic blood pressure (SBP), platelet counts, lymphocyte counts, and NLR (P<0.05), as well as a greater prevalence of high NLR than those without HT (37.5% vs.
20.7% and P=0.004).
Patients with HT were more likely to have hypertension and AF.
As lymphocyte counts and high NLR were highly correlated, we used two logistic regression models.
In model 1 (with high NLR), NIHSS score on admission (odds ratio (OR) = 1.110, 95% confidence interval (CI) = 1.015–1.044, and P=0.001), AF (OR = 3.986, 95% CI = 2.095–7.585, and P<0.001), and high NLR (OR = 2.078, 95% CI = 1.078–4.003, P=0.029, sensitivity 0.375, and specificity 0.793) were significant predictors of HT.
In model 2 (with lymphocyte counts), NIHSS score on admission (OR = 1.111, 95% CI = 1.050–1.175, and P<0.001), AF (OR = 3.853, 95% CI = 2.048–7.248, and P<0.001), and lymphocyte counts (OR = 0.522, 95% CI = 0.333–0.819, and P=0.005) were significantly associated with HT.
Conclusions.
High NLR could be a useful marker for predicting HT in AIS patients after IVT.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Liu, Yong-Lin& Lu, Jie-Kai& Yin, Han-Peng& Xia, Pei-Shan& Qiu, Dong-Hai& Liang, Man-Qiu…[et al.]. 2020. High Neutrophil-to-Lymphocyte Ratio Predicts Hemorrhagic Transformation in Acute Ischemic Stroke Patients Treated with Intravenous Thrombolysis. International Journal of Hypertension،Vol. 2020, no. 2020, pp.1-6.
https://search.emarefa.net/detail/BIM-1171699
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Liu, Yong-Lin…[et al.]. High Neutrophil-to-Lymphocyte Ratio Predicts Hemorrhagic Transformation in Acute Ischemic Stroke Patients Treated with Intravenous Thrombolysis. International Journal of Hypertension No. 2020 (2020), pp.1-6.
https://search.emarefa.net/detail/BIM-1171699
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Liu, Yong-Lin& Lu, Jie-Kai& Yin, Han-Peng& Xia, Pei-Shan& Qiu, Dong-Hai& Liang, Man-Qiu…[et al.]. High Neutrophil-to-Lymphocyte Ratio Predicts Hemorrhagic Transformation in Acute Ischemic Stroke Patients Treated with Intravenous Thrombolysis. International Journal of Hypertension. 2020. Vol. 2020, no. 2020, pp.1-6.
https://search.emarefa.net/detail/BIM-1171699
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1171699
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر