Assessment of Plasma Sodium to Potassium Ratio, Renal Function, Markers of Oxidative Stress, Inflammation, and Endothelial Dysfunction in Nigerian Hypertensive Patients
المؤلفون المشاركون
Ekun, Oloruntoba A.
Daniel, Folasade
Adebola, Philip
Ajibare, Adeola
Ekun, Oyeronke O.
Omogoroye, Oluwafunso O
Ilori, Oluwafemi S.
Oluwasayo, Bankole J.
Oshundun, Mary F.
Oyegbami, Sade R.
المصدر
International Journal of Hypertension
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-12-07
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Background.
This study investigated plasma sodium/potassium ratio, markers of oxidative stress, renal function, and endothelial dysfunction in hypertensive Nigerians.
Materials and Methods.
Five hundred forty-nine volunteers consisting of three hundred and twenty-four hypertensive and two hundred twenty-five controls participated in this study.
Blood samples were collected from the participants and were analyzed for electrolytes, markers of oxidative stress, endothelial dysfunction, renal function, and inflammation, using ion-selective electrodes, spectrophotometric, and enzyme-linked immunosorbent assay methods, respectively.
Results.
The mean systolic blood pressure, mean diastolic blood pressure, mean arterial blood pressure, and body mass index (BMI) were significantly elevated among the hypertensive group when compared with control (p<0.001).
The mean sodium increased, while potassium and bicarbonate (HCO3−) decreased (p<0.001) in hypertensive volunteers.
The sodium-potassium ratio (Na+/K+) and urea were raised (p<0.001) in the hypertensive group when compared with the control.
Glutathione, superoxide dismutase, nitric oxide (NO), and catalase were significantly reduced (p<0.001) while malondialdehyde (MDA), high-sensitivity C-reactive protein (hs-CRP), and ferritin were raised significantly (p<0.001) in hypertensive participants.
The odds of hypertension and its complications increased (p<0.001) with an increase in BMI, Na+/K+, hs-CRP, MDA, and ferritin and a decrease in estimated glomerular filtration rate (eGFR), glutathione, superoxide dismutase, and catalase.
Conclusion.
An increase in Na+/K+, urea, hs-CRP, ferritin, MDA, and BMI and a decrease in eGFR, glutathione, and superoxide dismutase were associated with an increased risk of hypertension complication.
Abnormal values of markers of oxidative stress, inflammation, and endothelial function could impact deleterious effects on the cardiovascular system among hypertensive Nigerians.
A decreased bicarbonate possibly suggests an occult acid-base imbalance among hypertensive volunteers.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ekun, Oloruntoba A.& Daniel, Folasade& Adebola, Philip& Ajibare, Adeola& Ekun, Oyeronke O.& Omogoroye, Oluwafunso O…[et al.]. 2020. Assessment of Plasma Sodium to Potassium Ratio, Renal Function, Markers of Oxidative Stress, Inflammation, and Endothelial Dysfunction in Nigerian Hypertensive Patients. International Journal of Hypertension،Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1171718
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ekun, Oloruntoba A.…[et al.]. Assessment of Plasma Sodium to Potassium Ratio, Renal Function, Markers of Oxidative Stress, Inflammation, and Endothelial Dysfunction in Nigerian Hypertensive Patients. International Journal of Hypertension No. 2020 (2020), pp.1-8.
https://search.emarefa.net/detail/BIM-1171718
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ekun, Oloruntoba A.& Daniel, Folasade& Adebola, Philip& Ajibare, Adeola& Ekun, Oyeronke O.& Omogoroye, Oluwafunso O…[et al.]. Assessment of Plasma Sodium to Potassium Ratio, Renal Function, Markers of Oxidative Stress, Inflammation, and Endothelial Dysfunction in Nigerian Hypertensive Patients. International Journal of Hypertension. 2020. Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1171718
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1171718
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر