Intranasal Insulin Administration Does Not Affect LH Concentrations in Men with Diabetes
المؤلفون المشاركون
Ghanim, Husam
Dhindsa, Sandeep
Chemitiganti, Rama
Santiago, Evangelina
Haider, Adnan
Chaar, Natalia
Mok, Mary
McKee, Alexis
Dandona, Paresh K.
المصدر
International Journal of Endocrinology
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-10-31
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
A quarter of men with obesity or type 2 diabetes have hypogonadotropic hypogonadism.
Animal studies and in vitro data have shown that insulin action and insulin responsiveness in the brain are necessary for the maintenance of the functional integrity of the hypothalamo-hypophyseal-gonadal axis.
We conducted a randomized, placebo-controlled trial to evaluate the effect of one dose of intranasal insulin (40 IU of regular insulin) or saline on LH concentrations in 14 men (8 with type 2 diabetes and 6 healthy lean men).
Insulin or saline was administered intranasally on two different occasions, at least one week apart.
Blood samples were collected to measure LH concentrations every 15 minutes for 5 hours.
Study drug was administered intranasally after a 2-hour baseline sampling period.
Patients remained fasting throughout the procedure.
The primary endpoint of the study was to compare the change in LH concentrations after intranasal insulin as compared to placebo (intranasal saline).
Change was defined as the difference between baseline LH concentrations (average of the 9 samples collected in two hours prior to drug administration) and average LH concentrations following drug administration (average of the 12 samples collected in 3 hours).
There was no change in LH concentrations following insulin administration as compared to placebo in men with diabetes or in lean men.
We conclude that one dose of 40 IU of regular insulin administered intranasally does not change LH concentrations acutely in men.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Dhindsa, Sandeep& Chemitiganti, Rama& Ghanim, Husam& Santiago, Evangelina& Haider, Adnan& Chaar, Natalia…[et al.]. 2018. Intranasal Insulin Administration Does Not Affect LH Concentrations in Men with Diabetes. International Journal of Endocrinology،Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1171740
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Dhindsa, Sandeep…[et al.]. Intranasal Insulin Administration Does Not Affect LH Concentrations in Men with Diabetes. International Journal of Endocrinology No. 2018 (2018), pp.1-7.
https://search.emarefa.net/detail/BIM-1171740
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Dhindsa, Sandeep& Chemitiganti, Rama& Ghanim, Husam& Santiago, Evangelina& Haider, Adnan& Chaar, Natalia…[et al.]. Intranasal Insulin Administration Does Not Affect LH Concentrations in Men with Diabetes. International Journal of Endocrinology. 2018. Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1171740
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1171740
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر