Circulating MicroRNAs as Biomarkers of Gestational Diabetes Mellitus: Updates and Perspectives
المؤلفون المشاركون
Dotta, Francesco
Sebastiani, Guido
Guarino, Elisa
Delli Poggi, Chiara
Grieco, Giuseppina Emanuela
Cenci, Valeria
Ceccarelli, Elena
Crisci, Isabella
المصدر
International Journal of Endocrinology
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-04-12
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Gestational diabetes mellitus (GDM) is defined as any degree of carbohydrate intolerance, with onset or first recognition during second or third trimester of gestation.
It is estimated that approximately 7% of all pregnancies are complicated by GDM and that its prevalence is rising all over the world.
Thus, the screening for abnormal glucose levels is generally recommended as a routine component of care for pregnant women.
However, additional biomarkers are needed in order to predict the onset or accurately monitor the status of gestational diabetes.
Recently, microRNAs, a class of small noncoding RNAs demonstrated to modulate gene expression, have been proven to be secreted by cells of origin and can be found in many biological fluids such as serum or plasma.
Such feature renders microRNAs as optimal biomarkers and sensors of in situ tissue alterations.
Furthermore, secretion of microRNAs via exosomes has been reported to contribute to tissue cross talk, thus potentially represents, if disrupted, a mechanistic cause of tissue/cell dysfunction in a specific disease.
In this review, we summarized the recent findings on circulating microRNAs and gestational diabetes mellitus with particular focus on the potential use of microRNAs as putative biomarkers of disease as well as a potential cause of GDM complications and β cell dysfunction.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Guarino, Elisa& Delli Poggi, Chiara& Grieco, Giuseppina Emanuela& Cenci, Valeria& Ceccarelli, Elena& Crisci, Isabella…[et al.]. 2018. Circulating MicroRNAs as Biomarkers of Gestational Diabetes Mellitus: Updates and Perspectives. International Journal of Endocrinology،Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1171765
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Guarino, Elisa…[et al.]. Circulating MicroRNAs as Biomarkers of Gestational Diabetes Mellitus: Updates and Perspectives. International Journal of Endocrinology No. 2018 (2018), pp.1-11.
https://search.emarefa.net/detail/BIM-1171765
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Guarino, Elisa& Delli Poggi, Chiara& Grieco, Giuseppina Emanuela& Cenci, Valeria& Ceccarelli, Elena& Crisci, Isabella…[et al.]. Circulating MicroRNAs as Biomarkers of Gestational Diabetes Mellitus: Updates and Perspectives. International Journal of Endocrinology. 2018. Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1171765
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1171765
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر