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GH, IGF-1, and Age Are Important Contributors to Thyroid Abnormalities in Patients with Acromegaly
المؤلفون المشاركون
Guo, Xiaopeng
Lian, Wei
Xing, Bing
Gao, Lu
Wang, Zihao
Wang, Qiang
Wu, Xia
Liu, Wei
Sun, Jian
المصدر
International Journal of Endocrinology
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-01-15
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Purpose.
To determine the prevalence, risk factors, and possible mechanisms of structural and endocrinological changes to the thyroid in acromegaly.
Methods.
We studied 93 acromegalic patients from PUMCH between January 2013 and December 2013.
The demographic and clinical information were recorded.
Specimens of pituitary adenomas and thyroid cancer were collected for BRAF mutation assessments.
Results.
Thyroid morphological abnormalities were found in 72 (77.4%) patients.
Three (3.2%) were diagnosed with thyroid cancer.
The thyroid gland volume was significantly increased in patients with higher random GH (p=0.01), higher nadir GH (p=0.008), and higher IGF-1 level (p=0.018).
Age (p=0.002) was an independent risk factor for thyroid morphological abnormalities in acromegaly.
The GH burden was significantly higher in patients with thyroid morphological abnormalities (p=0.036).
The BRAF V600E mutation was detected in the PTCs of the two patients with thyroid cancer.
Conclusions.
Both benign and malignant thyroid abnormalities are increased in the acromegalic population compared to those in the general population.
Age at diagnosis is an independent risk factor for thyroid abnormalities, and GH burden may be a partial contributor.
Early diagnosis, early treatment, and monitoring of postoperational endocrine levels are important for acromegalic patients.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wu, Xia& Gao, Lu& Guo, Xiaopeng& Wang, Qiang& Wang, Zihao& Lian, Wei…[et al.]. 2018. GH, IGF-1, and Age Are Important Contributors to Thyroid Abnormalities in Patients with Acromegaly. International Journal of Endocrinology،Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1171817
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wu, Xia…[et al.]. GH, IGF-1, and Age Are Important Contributors to Thyroid Abnormalities in Patients with Acromegaly. International Journal of Endocrinology No. 2018 (2018), pp.1-8.
https://search.emarefa.net/detail/BIM-1171817
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wu, Xia& Gao, Lu& Guo, Xiaopeng& Wang, Qiang& Wang, Zihao& Lian, Wei…[et al.]. GH, IGF-1, and Age Are Important Contributors to Thyroid Abnormalities in Patients with Acromegaly. International Journal of Endocrinology. 2018. Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1171817
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1171817
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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