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Fluconazole-Pyridoxine Bis-Triazolium Compounds with Potent Activity against Pathogenic Bacteria and Fungi Including Their Biofilm-Embedded Forms
المؤلفون المشاركون
Kayumov, Airat R.
Shtyrlin, Yurii G.
Bondar, Oksana V.
Garipov, Marsel R.
Pavelyev, Roman S.
Lisovskaya, Svetlana A.
Nikitina, Elena V.
Sabirova, Alina E.
Malanyeva, Albina G.
Aimaletdinov, Alexander M.
Iksanova, Alfia G.
Balakin, Konstantin V.
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-15، 15ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-12-27
دولة النشر
مصر
عدد الصفحات
15
التخصصات الرئيسية
الملخص EN
Two novel quaternary ammonium salts, bis-triazolium derivatives of fluconazole and pyridoxine, were synthesized by reaction of fluconazole with pyridoxine-based synthetic intermediates.
The leading compound demonstrated pronounced antimycotic and antibacterial in vitro activity, comparable to or exceeding that of the reference antifungal (fluconazole, terbinafine) and antibacterial/antiseptic (miramistin, benzalkonium chloride) agents.
In contrast to many antimicrobials, the leading compound was also active against biofilm-embedded staphylococci and Escherichia coli.
While no biofilm structure destruction occurred, all compounds were able to diffuse into the matrix and reduce the number of colony-forming units by three orders of magnitude at 16 × MBC.
The leading compound was significantly less toxic than miramistin and benzalkonium chloride and more toxic than the reference antifungal drugs.
The obtained results make the described chemotype a promising starting point for the development of new broad-spectrum antimicrobial therapies with powerful effect on fungal and bacterial pathogens including their biofilm-embedded forms.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Garipov, Marsel R.& Pavelyev, Roman S.& Lisovskaya, Svetlana A.& Nikitina, Elena V.& Kayumov, Airat R.& Sabirova, Alina E.…[et al.]. 2017. Fluconazole-Pyridoxine Bis-Triazolium Compounds with Potent Activity against Pathogenic Bacteria and Fungi Including Their Biofilm-Embedded Forms. Journal of Chemistry،Vol. 2017, no. 2017, pp.1-15.
https://search.emarefa.net/detail/BIM-1171895
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Garipov, Marsel R.…[et al.]. Fluconazole-Pyridoxine Bis-Triazolium Compounds with Potent Activity against Pathogenic Bacteria and Fungi Including Their Biofilm-Embedded Forms. Journal of Chemistry No. 2017 (2017), pp.1-15.
https://search.emarefa.net/detail/BIM-1171895
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Garipov, Marsel R.& Pavelyev, Roman S.& Lisovskaya, Svetlana A.& Nikitina, Elena V.& Kayumov, Airat R.& Sabirova, Alina E.…[et al.]. Fluconazole-Pyridoxine Bis-Triazolium Compounds with Potent Activity against Pathogenic Bacteria and Fungi Including Their Biofilm-Embedded Forms. Journal of Chemistry. 2017. Vol. 2017, no. 2017, pp.1-15.
https://search.emarefa.net/detail/BIM-1171895
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1171895
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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