C1qTNF-Related Protein5 (CTRP5) as a Biomarker to Predict Metabolic Syndrome and Each of Its Components
المؤلفون المشاركون
Yang, Gangyi
Yang, Min
Li, Ling
Liu, Hua
Jiang, Feiyu
Zhao, Xili
Liu, Rui
Liu, Dongfang
Zheng, Hongting
Zhu, Zhiming
المصدر
International Journal of Endocrinology
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-11-22
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Objective.
C1q/TNF-related protein5 (CTRP5) is a member of the C1q/tumor necrosis factor α- (TNF-α-) related protein family and has been reported to be associated with the regulation of glucose and lipid metabolism.
However, the clinical association between CTRP5 and metabolic syndrome (MetS) has not been reported.
The aim of the current study is to investigate the association between CTRP5 and MetS by a cross-sectional study.
Methods.
We performed a cross-sectional study in a Chinese population including 89 controls and 88 MetS individuals.
Serum CTRP5 concentrations were determined by ELISA.
The relationship between circulating CTRP5 and MetS and insulin resistance (IR) was assessed by Spearman’s correlation and multiple stepwise regression analysis.
Results.
Circulating CTRP5 concentrations were markedly decreased in MetS individuals relative to normal adults.
Overweight/obese individuals (BMI ≥ 25 kg/m2) showed a lower serum CTRP5 level than lean subjects (BMI < 25 kg/m2) in the study population (124.1 (99.12–147.37) vs.
103.9 (79.15–124.25) μg/L; P<0.01).
Circulating CTRP5 was found to be correlated negatively with BMI, FAT%, FBG, WHR, SBP, HbA1c, TG, 2-hour blood glucose after glucose overload (2-hOGTT), FIns, and HOMA-IR and positively with HDL-C (P<0.05 or P<0.01).
Binary logistic regression revealed that serum CTRP5 levels were associated with MetS.
In addition, serum CTRP5 levels gradually decreased with the increase in MetS components.
Conclusions.
Circulating CTRP5 is relative to the elevated risk of MetS in humans and may be in part through the effect of insulin resistance.
This trial is registered with ChiCTR-OCS-13003185.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Jiang, Feiyu& Yang, Min& Zhao, Xili& Liu, Rui& Yang, Gangyi& Liu, Dongfang…[et al.]. 2018. C1qTNF-Related Protein5 (CTRP5) as a Biomarker to Predict Metabolic Syndrome and Each of Its Components. International Journal of Endocrinology،Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1171901
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Jiang, Feiyu…[et al.]. C1qTNF-Related Protein5 (CTRP5) as a Biomarker to Predict Metabolic Syndrome and Each of Its Components. International Journal of Endocrinology No. 2018 (2018), pp.1-8.
https://search.emarefa.net/detail/BIM-1171901
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Jiang, Feiyu& Yang, Min& Zhao, Xili& Liu, Rui& Yang, Gangyi& Liu, Dongfang…[et al.]. C1qTNF-Related Protein5 (CTRP5) as a Biomarker to Predict Metabolic Syndrome and Each of Its Components. International Journal of Endocrinology. 2018. Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1171901
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1171901
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر