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Pharmacokinetic Comparisons of Mangiferin and Mangiferin Monosodium Salt in Rat Plasma by UPLC-MSMS
المؤلفون المشاركون
Guo, Hongbin
Chen, Mengqiao
Li, Mengran
Hu, Mingye
Chen, Baohua
Zhou, Chengyan
المصدر
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-11-14
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Mangiferin (MG) is an active component in natural medicines, and various studies have been reported on pharmacological effects, but the low solubility and bioavailability of MG limit its wide application.
The aim of the present study was to investigate the pharmacokinetic profiles of mangiferin (MG) and mangiferin monosodium salt (MG-Na) in rat plasma by UPLC-MS/MS, which were then compared between the two groups.
An appropriate high sensitivity and selectivity ultraperformance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) method was applied to the comparison of plasma pharmacokinetics in MG and MG-Na using carbamazepine as internal standard (IS).
These results showed that there were statistically significant differences in the pharmacokinetic parameters between MG and MG-Na after a single oral administration at 100 mg/kg.
When compared with pharmacokinetic parameters of MG, the AUC(0-t), AUC(0–∞), Cmax, K10, and Ka of MG-Na were increased by 5.6-, 5.7-, 20.8-, 8-, and 83.6-fold, while the Tmax and CL/F were decreased by 4- and 5.7-fold (P<0.001), respectively.
t1/2 value showed an increasing trend, but was statistically significant between the two groups.
Moreover, the AUC value in the MG-Na group was significantly increased and the relative bioavailability was calculated to be 570% when compared with that of the MG group.
These results suggested that the salification reaction of MG can effectively enhance gastrointestinal absorption and relative bioavailability by improving solubility and membrane permeability.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Guo, Hongbin& Chen, Mengqiao& Li, Mengran& Hu, Mingye& Chen, Baohua& Zhou, Chengyan. 2019. Pharmacokinetic Comparisons of Mangiferin and Mangiferin Monosodium Salt in Rat Plasma by UPLC-MSMS. Journal of Chemistry،Vol. 2019, no. 2019, pp.1-12.
https://search.emarefa.net/detail/BIM-1172013
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Guo, Hongbin…[et al.]. Pharmacokinetic Comparisons of Mangiferin and Mangiferin Monosodium Salt in Rat Plasma by UPLC-MSMS. Journal of Chemistry No. 2019 (2019), pp.1-12.
https://search.emarefa.net/detail/BIM-1172013
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Guo, Hongbin& Chen, Mengqiao& Li, Mengran& Hu, Mingye& Chen, Baohua& Zhou, Chengyan. Pharmacokinetic Comparisons of Mangiferin and Mangiferin Monosodium Salt in Rat Plasma by UPLC-MSMS. Journal of Chemistry. 2019. Vol. 2019, no. 2019, pp.1-12.
https://search.emarefa.net/detail/BIM-1172013
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1172013
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
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