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Synergistic Effects of Dantrolene and Nimodipine on the Phenylephrine-Induced Contraction and ACh-Induced Relaxation in Aortic Rings from Diabetic Rats
المؤلفون المشاركون
Crespo, Maria J.
Roman, Marie
Matias, Jonathan
Morales, Myrna
Torres, Hector
Quidgley, Jose
المصدر
International Journal of Endocrinology
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-04-19
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Diabetics have a higher risk of developing cerebral vasospasms (CVSP) than nondiabetics.
The addition of the ryanodine receptor (RyR) blocker dantrolene to standard therapies reduces vasospasms in nondiabetics.
Whether diabetics with CVSP also benefit from this drug, however, is unknown.
We evaluated the effects of a 30 min incubation with dantrolene (50 μM), nimodipine (50 nM), and both drugs in combination, on phenylephrine- (PHE-) induced contraction and on acetylcholine- (ACh-) induced relaxation in aortic rings from streptozotocin (STZ) diabetic rats.
Age-matched, nondiabetic rats served as controls.
The oxidative stress markers malondialdehyde (MDA) and 4-hydroxyalkenal (4-HAE) were also evaluated in the presence and absence of dantrolene and nimodipine.
The combination of these two drugs acted synergistically to reduce the PHE-induced contraction by 80% in both diabetics and controls.
In contrast, it increased the Emax value for ACh-induced relaxation (from 56.46 ± 5.14% to 96.21 ± 7.50%; n=6, P<0.05), and it decreased MDA + 4-HAE values in diabetic rats only.
These results suggest that the combination of dantrolene and nimodipine benefits both diabetics and nondiabetics by decreasing arterial tone synergistically.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Crespo, Maria J.& Roman, Marie& Matias, Jonathan& Morales, Myrna& Torres, Hector& Quidgley, Jose. 2018. Synergistic Effects of Dantrolene and Nimodipine on the Phenylephrine-Induced Contraction and ACh-Induced Relaxation in Aortic Rings from Diabetic Rats. International Journal of Endocrinology،Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1172366
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Crespo, Maria J.…[et al.]. Synergistic Effects of Dantrolene and Nimodipine on the Phenylephrine-Induced Contraction and ACh-Induced Relaxation in Aortic Rings from Diabetic Rats. International Journal of Endocrinology No. 2018 (2018), pp.1-10.
https://search.emarefa.net/detail/BIM-1172366
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Crespo, Maria J.& Roman, Marie& Matias, Jonathan& Morales, Myrna& Torres, Hector& Quidgley, Jose. Synergistic Effects of Dantrolene and Nimodipine on the Phenylephrine-Induced Contraction and ACh-Induced Relaxation in Aortic Rings from Diabetic Rats. International Journal of Endocrinology. 2018. Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1172366
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1172366
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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