Spoligotype Diversity of Mycobacterium tuberculosis over Two Decades from Tiruvallur, South India
المؤلفون المشاركون
Ashok Kumar, S.
Sekar, Gomathi
Narayanan, P. R.
Narayanan, Sujatha
Tripathy, Srikanth Prasad
Mondal, Rajesh
Siva Kumar, S.
Devika, K.
Bhasker, M.
Dolla, C. K.
Menon, Pradeep Aravindan
Ranganathan, Uma Devi
Sriram, S.
المصدر
International Journal of Microbiology
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-10-14
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Geographically, most tuberculosis (TB) cases in 2018 were reported from India.
This TB burden is compounded by MDR-TB and XDR-TB.
The strategies for the management and control of TB in the community depend on an understanding of the mode of spread of the different strains of TB isolates in the community.
To determine the distribution and trends of M.
tb strains over the time period in the community due to treatment, we carried out the present study on changes over two decades.
Design/Methods.
A total of 1218 M.
tb isolates (year: 2001–2018) from Tiruvallur, India, were genotyped by spoligotyping after DNA extraction and subjected to anti-TB drug susceptibility testing for the first-line anti-TB drugs.
Results.
On analysis with the SpolDB4 database, majority (2001–2003: 53.32% and 2015–2018: 46.3%) of the isolates belonged to East African Indian (EAI) lineage, and the orphans designated in comparison to SpolDB4 stood 33% among 2001–2003 strain collection and 46.3% among 2015–2018 strain collection.
10.2% (2001–2003) and 9.26% (2015 to 2018) of isolates were monoresistant to isoniazid (H).
MDR strains were less common among EAI strains (3.2%) compared to non-EAI strains (10.32%).
Conclusions.
EAI is the most predominant lineage in Tiruvallur, despite the presence of highly transmissible lineages like Beijing for the last two decades.
The prevalence of MDR-TB is below the national average of 2-3% among the new TB cases in the last two decades.
The reason can be attributed to the well-established nature of the locally circulating strains in this region which are not associated with drug resistance.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Siva Kumar, S.& Ashok Kumar, S.& Sekar, Gomathi& Devika, K.& Bhasker, M.& Sriram, S.…[et al.]. 2020. Spoligotype Diversity of Mycobacterium tuberculosis over Two Decades from Tiruvallur, South India. International Journal of Microbiology،Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1172408
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Siva Kumar, S.…[et al.]. Spoligotype Diversity of Mycobacterium tuberculosis over Two Decades from Tiruvallur, South India. International Journal of Microbiology No. 2020 (2020), pp.1-7.
https://search.emarefa.net/detail/BIM-1172408
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Siva Kumar, S.& Ashok Kumar, S.& Sekar, Gomathi& Devika, K.& Bhasker, M.& Sriram, S.…[et al.]. Spoligotype Diversity of Mycobacterium tuberculosis over Two Decades from Tiruvallur, South India. International Journal of Microbiology. 2020. Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1172408
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1172408
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر