A Transdermal Measurement Platform Based on Microfluidics

المؤلفون المشاركون

Huang, Wen-Ying
Huang, Jung-Ping
Lin, Chia-Ching
Lin, Yung-Sheng

المصدر

Journal of Chemistry

العدد

المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-8، 8ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2017-12-25

دولة النشر

مصر

عدد الصفحات

8

التخصصات الرئيسية

الكيمياء

الملخص EN

The Franz diffusion cell is one of the most widely used devices to evaluate transdermal drug delivery.

However, this static and nonflowing system has some limitations, such as a relatively large solution volume and skin area and the development of gas bubbles during sampling.

To overcome these disadvantages, this study provides a proof of concept for miniaturizing models of transdermal delivery by using a microfluidic chip combined with a diffusion cell.

The proposed diffusion microchip system requires only 80 μL of sample solution and provides flow circulation.

Two model compounds, Coomassie Brilliant Blue G-250 and potassium ferricyanide, were successfully tested for transdermal delivery experiments.

The diffusion rate is high for a high sample concentration or a large membrane pore size.

The developed diffusion microchip system, which is feasible, can be applied for transdermal measurement in the future.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Huang, Wen-Ying& Huang, Jung-Ping& Lin, Chia-Ching& Lin, Yung-Sheng. 2017. A Transdermal Measurement Platform Based on Microfluidics. Journal of Chemistry،Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1172580

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Huang, Wen-Ying…[et al.]. A Transdermal Measurement Platform Based on Microfluidics. Journal of Chemistry No. 2017 (2017), pp.1-8.
https://search.emarefa.net/detail/BIM-1172580

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Huang, Wen-Ying& Huang, Jung-Ping& Lin, Chia-Ching& Lin, Yung-Sheng. A Transdermal Measurement Platform Based on Microfluidics. Journal of Chemistry. 2017. Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1172580

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-1172580