Myeloid-Derived Suppressor Cells Show Different Frequencies in Diabetics and Subjects with Arterial Hypertension
المؤلفون المشاركون
Garza-Veloz, Idalia
Cervantes-Villagrana, Alberto R.
Fernández-Ruiz, Julio C.
Galindo-De Ávila, Julia C.
Martínez-Fierro, Margarita L.
Valtierra-Alvarado, Monica A.
Serrano, Carmen J.
García-Hernández, Mariana H.
Enciso-Moreno, José A.
Castañeda-Delgado, Julio E.
المصدر
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-12-12
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Type 2 diabetes mellitus (DM2) is strongly associated with other comorbidities such as obesity, atherosclerosis, and hypertension.
Obesity is associated with sustained low-grade inflammatory response due to the production of proinflammatory cytokines.
This inflammatory process promotes the differentiation of some myeloid cells, including myeloid-derived suppressor cells (MDSCs).
In this study, two groups of individuals were included: DM2 patients and non-DM2 individuals with similar characteristics.
Immunolabeling of CD15+ CD14- and CD33+ HLA-DR-/low was performed from whole peripheral blood, and samples were analyzed by flow cytometry, and frequencies of MDSCs and the relationship of these with clinical variables, cytokine profile (measured by cytometric bead array), and anthropometric variables were analyzed.
The frequency of CD33+ HLA-DR-/low MDSCs (that produce IL-10 and TGF-β, according to an intracellular detection) is higher in patients with DM2 (P<0.05), and there is a positive correlation between the frequency of CD15+ CD14- and CD33+ HLA-DR-/low MDSC phenotypes.
DM2 patients have an increased concentration of serum IL-5 (P<0.05).
Also, a negative correlation between the frequency of CD15+ CD14- MDSCs and LDL cholesterol was found.
Our group of DM2 patients have an increased frequency of mononuclear MDSC CD33+ HLA-DR-/low that produce TGF-β and IL-10.
These cytokines have been associated with immune modulation and reduced T cell responses.
DM2 and non-DM2 subjects show a similar cytokine profile, but the DM2 patients have an increased concentration of IL-5.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Fernández-Ruiz, Julio C.& Galindo-De Ávila, Julia C.& Martínez-Fierro, Margarita L.& Garza-Veloz, Idalia& Cervantes-Villagrana, Alberto R.& Valtierra-Alvarado, Monica A.…[et al.]. 2019. Myeloid-Derived Suppressor Cells Show Different Frequencies in Diabetics and Subjects with Arterial Hypertension. Journal of Diabetes Research،Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1172712
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Fernández-Ruiz, Julio C.…[et al.]. Myeloid-Derived Suppressor Cells Show Different Frequencies in Diabetics and Subjects with Arterial Hypertension. Journal of Diabetes Research No. 2019 (2019), pp.1-10.
https://search.emarefa.net/detail/BIM-1172712
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Fernández-Ruiz, Julio C.& Galindo-De Ávila, Julia C.& Martínez-Fierro, Margarita L.& Garza-Veloz, Idalia& Cervantes-Villagrana, Alberto R.& Valtierra-Alvarado, Monica A.…[et al.]. Myeloid-Derived Suppressor Cells Show Different Frequencies in Diabetics and Subjects with Arterial Hypertension. Journal of Diabetes Research. 2019. Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1172712
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1172712
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر