No Race-Ethnicity Adjustment in CKD-EPI Equations Is Required for Estimating Glomerular Filtration Rate in the Brazilian Population
المؤلفون المشاركون
Carraro-Eduardo, José Carlos
Lugon, Jocemir Ronaldo
Rocha, Amanda D.
Garcia, Suzane
Santos, Andressa B.
Mesquita, Claudio T.
Strogoff-de-Matos, Jorge P.
المصدر
International Journal of Nephrology
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-07-18
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Background.
Glomerular filtration rate (GFR) is usually estimated from equations using serum creatinine (sCr), with adjustment for gender, age, and race (black or nonblack).
The Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) is the preferred equation for adults, but it was validated for the United States population.
We intended to evaluate if the race-ethnicity adjustment proposed for the sCr-based CKD-EPI equations is appropriate for the Brazilian population.
Methods.
CKD outpatients had blood samples collected for determination of sCr and serum cystatin C (sCys) levels.
GFR was measured (mGFR) by plasma clearance of 51Cr-EDTA and used as the reference.
We compared values of mGFR and estimated GFR (eGFR) by CKD-EPI equations based on sCr (eGFRCr) and on the combination of sCr and sCys (eGFRCr-Cys).
For African Brazilian patients, eGFR was calculated either without or with race adjustment.
Accuracy was considered acceptable if the difference between the values of eGFR and mGFR was ≤30% (P30).
Results.
100 patients were enrolled (58 ± 14 years, 46% male, 39% white and 61% African Brazilian).
Mean mGFR was 46.7 ± 29.2 ml/min/1.73 m2.
Mean eGFRCr and eGFRCr-Cys without race adjustment were 47.8 ± 30.1 ml/min/1.73 m2 and 46.4 ± 30.3 ml/min/1.73 m2, respectively.
The corresponding P30 accuracy values were 79.0% and 83.0%.
In the African Brazilian subgroup, values for mean mGFR and eGFRCr either without or with race adjustment were 49.8 ± 32.2 ml/min/1.73 m2, 50.4 ± 32.7 ml/min/1.73 m2, and 58.4 ± 37.9 ml/min/1.73 m2 (P<0.001 vs.
mGFR), respectively.
P30 accuracy values for eGFRCr either without or with race adjustment were 75.4% and 67.2%, respectively.
Conclusions.
The use of CKD-EPI equations without race-ethnicity adjustment seems more appropriate for the Brazilian population.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Rocha, Amanda D.& Garcia, Suzane& Santos, Andressa B.& Carraro-Eduardo, José Carlos& Mesquita, Claudio T.& Lugon, Jocemir Ronaldo…[et al.]. 2020. No Race-Ethnicity Adjustment in CKD-EPI Equations Is Required for Estimating Glomerular Filtration Rate in the Brazilian Population. International Journal of Nephrology،Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1172739
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Rocha, Amanda D.…[et al.]. No Race-Ethnicity Adjustment in CKD-EPI Equations Is Required for Estimating Glomerular Filtration Rate in the Brazilian Population. International Journal of Nephrology No. 2020 (2020), pp.1-9.
https://search.emarefa.net/detail/BIM-1172739
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Rocha, Amanda D.& Garcia, Suzane& Santos, Andressa B.& Carraro-Eduardo, José Carlos& Mesquita, Claudio T.& Lugon, Jocemir Ronaldo…[et al.]. No Race-Ethnicity Adjustment in CKD-EPI Equations Is Required for Estimating Glomerular Filtration Rate in the Brazilian Population. International Journal of Nephrology. 2020. Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1172739
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1172739
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر