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Low-Dose Maintenance Intravenous Iron Therapy Can Prevent Anemia in Children with End-Stage Renal Disease Undergoing Chronic Hemodialysis
المؤلفون المشاركون
Rachmadi, Dedi
Ambarsari, Cahyani Gita
Trihono, Partini Pudjiastuti
Kadaristiana, Agustina
Andriastuti, Murti
Puspitasari, Henny Adriani
Tambunan, Taralan
Pardede, Sudung Oloan
Mangunatmadja, Irawan
Hidayati, Eka Laksmi
المصدر
International Journal of Nephrology
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-06-01
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Iron deficiency anemia is common in children with end-stage renal disease (ESRD) on long-term hemodialysis receiving erythropoiesis-stimulating agents.
One approach to maintain the iron profile and hemoglobin levels is maintenance therapy with regular low doses of intravenous (IV) iron after initial iron repletion therapy; however, evidence for the benefits of this approach is lacking.
This study evaluated the effect of IV iron maintenance therapy on anemia in children on regular hemodialysis.
This retrospective cohort study included 41 pediatric ESRD patients with normal hemoglobin and iron status who underwent regular hemodialysis at the Pediatric Dialysis Unit of Cipto Mangunkusumo Hospital, Indonesia, between January 2015 and April 2019.
Among these, 21 received IV iron maintenance therapy with two doses of 2 mg/kg of IV iron sucrose every 2 weeks (the treatment group) and 20 did not (the comparison group).
Changes in hemoglobin and transferrin saturation were assessed after 6 weeks of observation and compared between the two groups.
There was a significant reduction in the mean hemoglobin level compared with the baseline level in the comparison group (21 g/L; 95% CI, 9.3–33 g/L; p=0.001) but not in the treatment group (0.7 g/L; 95% CI, −6.6–8 g/L; p=0.84).
The risk of anemia was lower in the treatment group (relative risk = 0.42; 95% CI, 0.22–0.79; p=0.003).
Although majority of the patients had high baseline ferritin level, this study indicates that in our setting, ferritin may not be a reliable parameter to review the iron status, as it can be affected by chronic inflammation.
Hence, the decision to start IV iron maintenance therapy in patients with hyperferritinemia should consider the patient’s clinical condition and morbidity.
To conclude, the coadministration of IV iron maintenance therapy is beneficial for maintaining hemoglobin levels and preventing anemia in children with ESRD who are undergoing regular hemodialysis, have achieved the target hemoglobin levels, and have normal iron status.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ambarsari, Cahyani Gita& Trihono, Partini Pudjiastuti& Kadaristiana, Agustina& Rachmadi, Dedi& Andriastuti, Murti& Puspitasari, Henny Adriani…[et al.]. 2020. Low-Dose Maintenance Intravenous Iron Therapy Can Prevent Anemia in Children with End-Stage Renal Disease Undergoing Chronic Hemodialysis. International Journal of Nephrology،Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1172752
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ambarsari, Cahyani Gita…[et al.]. Low-Dose Maintenance Intravenous Iron Therapy Can Prevent Anemia in Children with End-Stage Renal Disease Undergoing Chronic Hemodialysis. International Journal of Nephrology No. 2020 (2020), pp.1-8.
https://search.emarefa.net/detail/BIM-1172752
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ambarsari, Cahyani Gita& Trihono, Partini Pudjiastuti& Kadaristiana, Agustina& Rachmadi, Dedi& Andriastuti, Murti& Puspitasari, Henny Adriani…[et al.]. Low-Dose Maintenance Intravenous Iron Therapy Can Prevent Anemia in Children with End-Stage Renal Disease Undergoing Chronic Hemodialysis. International Journal of Nephrology. 2020. Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1172752
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1172752
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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