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The Effect of Shear Force on Skin Viability in Patients with Type 2 Diabetes
المؤلفون المشاركون
Bouvy, Nicole D.
Poeze, Martijn
de Wert, Luuk A.
Geerts, Margot
van der Brug, Sander
Adriaansen, Laura
Schaper, Nicolaas
المصدر
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-11-04
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Background.
Shear is a major risk factor in the development of diabetic foot ulcers, but its effect on the skin of patients with type 2 diabetes mellitus (DM) remains to be elucidated.
The aim was to determine skin responses to shear in DM patients with and without diabetic polyneuropathy (DNP).
Methods.
The forearm skin was loaded with 14.5 N shear (+2.4 kPa pressure) and with 3.5 kPa pressure for 30 minutes in 10 type 2 DM patients without DNP, 10 type 2 DM patients with DNP, and 10 healthy participants.
A Sebutape collected IL-1α (measure of tissue damage).
A laser Doppler flowmeter measured cutaneous blood cell flux (CBF) as a measure of the reactive hyperaemic skin response.
Findings.
Reactive hyperaemia and IL-1α release was significantly increased after shear loading in all three groups and was higher compared to the responses to pressure loading.
The reactive hyperaemic response after shear loading was impaired in patients with type 2 DM compared to healthy participants but did not differ between patients with and without DNP.
The reactive hyperaemic response was negatively correlated with the blood glucose level but did not correlate with the DNP severity score.
Interpretation.
Shear is important in the development of tissue damage, but the reparative responses to shear are impaired in patients with type 2 DM.
DNP was not associated with altered skin responses, suggesting that the loss of protective sensation to sense shear to skin remains a key factor in the development of diabetic foot ulcers in patients with DNP.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
de Wert, Luuk A.& Geerts, Margot& van der Brug, Sander& Adriaansen, Laura& Poeze, Martijn& Schaper, Nicolaas…[et al.]. 2019. The Effect of Shear Force on Skin Viability in Patients with Type 2 Diabetes. Journal of Diabetes Research،Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1172771
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
de Wert, Luuk A.…[et al.]. The Effect of Shear Force on Skin Viability in Patients with Type 2 Diabetes. Journal of Diabetes Research No. 2019 (2019), pp.1-9.
https://search.emarefa.net/detail/BIM-1172771
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
de Wert, Luuk A.& Geerts, Margot& van der Brug, Sander& Adriaansen, Laura& Poeze, Martijn& Schaper, Nicolaas…[et al.]. The Effect of Shear Force on Skin Viability in Patients with Type 2 Diabetes. Journal of Diabetes Research. 2019. Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1172771
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1172771
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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