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Platelet Serotonin Levels Are Associated with Plasma Soluble Leptin Receptor Concentrations in Normoglycemic Women
المؤلفون المشاركون
Cataldo, L. R.
Olmos, P.
Galgani, J. E.
Santos, J. L.
Suazo, José
Bravo, Carolina
Fex, Malin
Martínez, J. Alfredo
المصدر
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-05-02
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Most peripheral serotonin (5-hydroxytryptamine (5HT)) is synthetized in the gut with platelets being its main circulating reservoir.
5HT is acting as a hormone in key organs to regulate glucose and lipid metabolism.
However, the relation between platelet 5HT levels and traits related to glucose homeostasis and lipid metabolism in humans remains poorly explored.
The objectives of this study were (a) to assess the association between platelet 5HT levels and plasma concentration of nonesterified fatty acids (NEFAs) and some adipokines including leptin and its soluble leptin receptor (sOb-R), (b) to assess the association between platelet 5HT levels and anthropometric traits and indexes of insulin secretion/sensitivity derived from oral glucose tolerance test (OGTT), and (c) to evaluate changes in platelet 5HT levels in response to OGTT.
In a cross-sectional study, 59 normoglycemic women underwent a standard 2-hour OGTT.
Plasma leptin, sOb-R, total and high molecular weight adiponectin, TNFα, and MCP1 were determined by immunoassays.
Platelet 5HT levels and NEFAs were measured before and after OGTT.
The free leptin index was calculated from leptin and sOb-R measurements.
Insulin sensitivity indexes derived from OGTT (HOMA-S and Matsuda ISICOMP) and plasma NEFAs (Adipose-IR, Revised QUICKI) were also calculated.
Our data show that among metabolic traits, platelet 5HT levels were associated with plasma sOb-R (r=0.39, p=0.003, corrected p=0.018).
Platelet 5HT levels were reduced in response to OGTT (779±237 vs.731±217 ng/109 platelets, p=0.005).
In conclusion, platelet 5HT levels are positively associated with plasma sOb-R concentrations and reduced in response to glucose intake possibly indicating a role of peripheral 5HT in leptin-mediated appetite regulation.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Cataldo, L. R.& Suazo, José& Olmos, P.& Bravo, Carolina& Galgani, J. E.& Fex, Malin…[et al.]. 2019. Platelet Serotonin Levels Are Associated with Plasma Soluble Leptin Receptor Concentrations in Normoglycemic Women. Journal of Diabetes Research،Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1172850
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Cataldo, L. R.…[et al.]. Platelet Serotonin Levels Are Associated with Plasma Soluble Leptin Receptor Concentrations in Normoglycemic Women. Journal of Diabetes Research No. 2019 (2019), pp.1-10.
https://search.emarefa.net/detail/BIM-1172850
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Cataldo, L. R.& Suazo, José& Olmos, P.& Bravo, Carolina& Galgani, J. E.& Fex, Malin…[et al.]. Platelet Serotonin Levels Are Associated with Plasma Soluble Leptin Receptor Concentrations in Normoglycemic Women. Journal of Diabetes Research. 2019. Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1172850
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1172850
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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