Systems Pharmacology-Based Approach of Connecting Disease Genes in Genome-Wide Association Studies with Traditional Chinese Medicine
المؤلفون المشاركون
Tan, Aik Choon
Kim, Jihye
Yoo, Minjae
Shin, Jimin
Kim, Hyunmin
Kang, Jaewoo
المصدر
International Journal of Genomics
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-03-22
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Traditional Chinese medicine (TCM) originated in ancient China has been practiced over thousands of years for treating various symptoms and diseases.
However, the molecular mechanisms of TCM in treating these diseases remain unknown.
In this study, we employ a systems pharmacology-based approach for connecting GWAS diseases with TCM for potential drug repurposing and repositioning.
We studied 102 TCM components and their target genes by analyzing microarray gene expression experiments.
We constructed disease-gene networks from 2558 GWAS studies.
We applied a systems pharmacology approach to prioritize disease-target genes.
Using this bioinformatics approach, we analyzed 14,713 GWAS disease-TCM-target gene pairs and identified 115 disease-gene pairs with q value < 0.2.
We validated several of these GWAS disease-TCM-target gene pairs with literature evidence, demonstrating that this computational approach could reveal novel indications for TCM.
We also develop TCM-Disease web application to facilitate the traditional Chinese medicine drug repurposing efforts.
Systems pharmacology is a promising approach for connecting GWAS diseases with TCM for potential drug repurposing and repositioning.
The computational approaches described in this study could be easily expandable to other disease-gene network analysis.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Kim, Jihye& Yoo, Minjae& Shin, Jimin& Kim, Hyunmin& Kang, Jaewoo& Tan, Aik Choon. 2018. Systems Pharmacology-Based Approach of Connecting Disease Genes in Genome-Wide Association Studies with Traditional Chinese Medicine. International Journal of Genomics،Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1172852
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Kim, Jihye…[et al.]. Systems Pharmacology-Based Approach of Connecting Disease Genes in Genome-Wide Association Studies with Traditional Chinese Medicine. International Journal of Genomics No. 2018 (2018), pp.1-11.
https://search.emarefa.net/detail/BIM-1172852
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Kim, Jihye& Yoo, Minjae& Shin, Jimin& Kim, Hyunmin& Kang, Jaewoo& Tan, Aik Choon. Systems Pharmacology-Based Approach of Connecting Disease Genes in Genome-Wide Association Studies with Traditional Chinese Medicine. International Journal of Genomics. 2018. Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1172852
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1172852
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر