The Influence of Metabolic Syndrome and Sex on the DNA Methylome in Schizophrenia
المؤلفون المشاركون
Ellingrod, Vicki L.
Goodrich, Jacyln M.
Lines, Brittany N.
Burghardt, Kyle J.
المصدر
International Journal of Genomics
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-04-03
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Introduction.
The mechanism by which metabolic syndrome occurs in schizophrenia is not completely known; however, previous work suggests that changes in DNA methylation may be involved which is further influenced by sex.
Within this study, the DNA methylome was profiled to identify altered methylation associated with metabolic syndrome in a schizophrenia population on atypical antipsychotics.
Methods.
Peripheral blood from schizophrenia subjects was utilized for DNA methylation analyses.
Discovery analyses (n=96) were performed using an epigenome-wide analysis on the Illumina HumanMethylation450K BeadChip based on metabolic syndrome diagnosis.
A secondary discovery analysis was conducted based on sex.
The top hits from the discovery analyses were assessed in an additional validation set (n=166) using site-specific methylation pyrosequencing.
Results.
A significant increase in CDH22 gene methylation in subjects with metabolic syndrome was identified in the overall sample.
Additionally, differential methylation was found within the MAP3K13 gene in females and the CCDC8 gene within males.
Significant differences in methylation were again observed for the CDH22 and MAP3K13 genes, but not CCDC8, in the validation sample set.
Conclusions.
This study provides preliminary evidence that DNA methylation may be associated with metabolic syndrome and sex in schizophrenia.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Burghardt, Kyle J.& Goodrich, Jacyln M.& Lines, Brittany N.& Ellingrod, Vicki L.. 2018. The Influence of Metabolic Syndrome and Sex on the DNA Methylome in Schizophrenia. International Journal of Genomics،Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1172864
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Burghardt, Kyle J.…[et al.]. The Influence of Metabolic Syndrome and Sex on the DNA Methylome in Schizophrenia. International Journal of Genomics No. 2018 (2018), pp.1-12.
https://search.emarefa.net/detail/BIM-1172864
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Burghardt, Kyle J.& Goodrich, Jacyln M.& Lines, Brittany N.& Ellingrod, Vicki L.. The Influence of Metabolic Syndrome and Sex on the DNA Methylome in Schizophrenia. International Journal of Genomics. 2018. Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1172864
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1172864
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر