Insulin Glargine U100 Utilization in Patients with Type 2 Diabetes in an Italian Real-World Setting: A Retrospective Study
المؤلفون المشاركون
Degli Esposti, Luca
Perrone, Valentina
Saragoni, Stefania
Blini, Valerio
Buda, Stefano
D’avella, Rosella
Gasperini, Gina
Lena, Fabio
Fanelli, Francesca
Gazzi, Luca
Giorgino, F.
المصدر
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-12-31
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Background.
This study is aimed at estimating the proportion of type 2 diabetes mellitus (T2DM) patients treated with basal insulin (insulin glargine U100) and at evaluating daily insulin dose, treatment pattern, and adherence to treatment of these patients.
Methods.
Data from administrative and laboratory databases of 3 Italian Local Health Units were retrospectively collected and analyzed.
All patients with a diagnosis of T2DM between 01/01/2012 and 31/12/2012 were considered, and those with at least a prescription of insulin glargine between 01/01/2013 and 31/12/2014 were included and followed up for one year.
For each patient, we evaluated HbA1c levels both at baseline and during the follow-up period and the daily average dose of insulin.
Medication adherence was defined by using medication possession ratio (MPR) and reported as proportion of patients with MPR≥80%.
Results.
7,422 T2DM patients were available for the study.
According to the antidiabetic medication prescribed, patients were categorized into four groups: insulin glargine only, insulin glargine plus oral glucose-lowering drugs, insulin glargine plus rapid-acting insulin, and insulin glargine plus DPP-4 inhibitors.
Median daily dose of insulin among insulin glargine only patients was higher than in other groups (35 IU vs.
20 IU, p<0.05), and a higher percentage of them achieved a target HbA1c value of less than 7.0% (53.8% vs.
30%, p<0.001).
Adherence to insulin treatment was lowest (41%) in the insulin glargine only group compared to other groups (ranging from 58.4% to 64.4%), p<0.001.
Conclusions.
A large proportion of T2DM patients treated with insulin fail in achieving the glycemic target of HbA1c level<7%, irrespective of treatment regimen; however, basal insulin only is associated with lower therapeutic unsuccess.
Adherence to antidiabetes medications is also suboptimal in these patients and should be addressed to improve long-term outcomes of reducing and preventing microvascular and macrovascular complications.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Degli Esposti, Luca& Perrone, Valentina& Saragoni, Stefania& Blini, Valerio& Buda, Stefano& D’avella, Rosella…[et al.]. 2019. Insulin Glargine U100 Utilization in Patients with Type 2 Diabetes in an Italian Real-World Setting: A Retrospective Study. Journal of Diabetes Research،Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1172874
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Degli Esposti, Luca…[et al.]. Insulin Glargine U100 Utilization in Patients with Type 2 Diabetes in an Italian Real-World Setting: A Retrospective Study. Journal of Diabetes Research No. 2019 (2019), pp.1-10.
https://search.emarefa.net/detail/BIM-1172874
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Degli Esposti, Luca& Perrone, Valentina& Saragoni, Stefania& Blini, Valerio& Buda, Stefano& D’avella, Rosella…[et al.]. Insulin Glargine U100 Utilization in Patients with Type 2 Diabetes in an Italian Real-World Setting: A Retrospective Study. Journal of Diabetes Research. 2019. Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1172874
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1172874
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر