The Progress of Methylation Regulation in Gene Expression of Cervical Cancer

المؤلفون المشاركون

Cui, Manhua
Chang, Weiqin
Feng, Chunyang
Xu, Tianmin
Dong, Junxue

المصدر

International Journal of Genomics

العدد

المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-11، 11ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2018-04-16

دولة النشر

مصر

عدد الصفحات

11

التخصصات الرئيسية

الأحياء

الملخص EN

Cervical cancer is one of the most common gynecological tumors in females, which is closely related to high-rate HPV infection.

Methylation alteration is a type of epigenetic decoration that regulates the expression of genes without changing the DNA sequence, and it is essential for the progression of cervical cancer in pathogenesis while reflecting the prognosis and therapeutic sensitivity in clinical practice.

Hydroxymethylation has been discovered in recent years, thus making 5-hmC, the more stable marker, attract more attention in the field of methylation research.

As markers of methylation, 5-hmC and 5-mC together with 5-foC and 5-caC draw the outline of the reversible cycle, and 6-mA takes part in the methylation of RNA, especially mRNA.

Furthermore, methylation modification participates in ncRNA regulation and histone decoration.

In this review, we focus on recent advances in the understanding of methylation regulation in the process of cervical cancer, as well as HPV and CIN, to identify the significant impact on the prospect of overcoming cervical cancer.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Feng, Chunyang& Dong, Junxue& Chang, Weiqin& Cui, Manhua& Xu, Tianmin. 2018. The Progress of Methylation Regulation in Gene Expression of Cervical Cancer. International Journal of Genomics،Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1172879

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Feng, Chunyang…[et al.]. The Progress of Methylation Regulation in Gene Expression of Cervical Cancer. International Journal of Genomics No. 2018 (2018), pp.1-11.
https://search.emarefa.net/detail/BIM-1172879

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Feng, Chunyang& Dong, Junxue& Chang, Weiqin& Cui, Manhua& Xu, Tianmin. The Progress of Methylation Regulation in Gene Expression of Cervical Cancer. International Journal of Genomics. 2018. Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1172879

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-1172879