Protective Effects of Konjac and Inulin Extracts on Type 1 and Type 2 Diabetes
المؤلفون المشاركون
Gao, Tianle
Jiao, Yue
Liu, Yang
Li, Tao
Wang, Zhiguo
Wang, Danqiao
المصدر
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-10-07
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Objective.
The present study was designed to determine whether konjac and inulin extracts or their combination, konjac-inulin (KI) composition, as diet supplementary, can exert beneficial effects against type 1 diabetes and type 2 diabetes using animal models.
Methods.
A total of 60 diabetic (type 1) rats induced by streptozotocin (STZ) were randomly assigned to five groups: vehicle control (STZ group), KI combination at low dose group (KI-L group), KI combination at medium dose group (KI-M group), KI combination at high dose group (KI-H group), konjac extract group (konjac group), and inulin extract group (inulin group).
A sham group (without STZ) was also included.
Levels of blood glucose were monitored at each week.
After continuous treatment of each diet for 24 days, a glucose tolerance test was performed.
After 28 days of treatment, plasma biochemical indicators including glycated serum proteins, total cholesterol, and triglycerides were measured and immunohistochemistry staining of the rat pancreas was performed, to study the insulin expressions.
Type 2 diabetes was developed in db/db mice.
A total of 28 db/db mice were divided into 4 groups: vehicle control (db/db group), KI composition group (KI group), konjac extract group (konjac group), and inulin extract group (inulin group).
A wild-type control group (wild-type group) for db/db mice was also included.
Levels of blood glucose, body weight, and blood triglycerides were monitored at each week.
Results.
Daily use of the KI composition significantly decreased levels of blood glucose and blood triglycerides, as well as improved the insulin production in islets or reduced development of obesity in STZ-induced diabetic rats or in db/db mice.
Such effects from KI composition were better than single ingredient of konjac or inulin extract.
Conclusion.
The results of this study suggest that daily use of KI composition has a protective role on type 1 and 2 diabetes and provided experimental basis for further development of KI composition as a food supplement for diabetic or diabetic high-risk population.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Gao, Tianle& Jiao, Yue& Liu, Yang& Li, Tao& Wang, Zhiguo& Wang, Danqiao. 2019. Protective Effects of Konjac and Inulin Extracts on Type 1 and Type 2 Diabetes. Journal of Diabetes Research،Vol. 2019, no. 2019, pp.1-12.
https://search.emarefa.net/detail/BIM-1172893
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Gao, Tianle…[et al.]. Protective Effects of Konjac and Inulin Extracts on Type 1 and Type 2 Diabetes. Journal of Diabetes Research No. 2019 (2019), pp.1-12.
https://search.emarefa.net/detail/BIM-1172893
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Gao, Tianle& Jiao, Yue& Liu, Yang& Li, Tao& Wang, Zhiguo& Wang, Danqiao. Protective Effects of Konjac and Inulin Extracts on Type 1 and Type 2 Diabetes. Journal of Diabetes Research. 2019. Vol. 2019, no. 2019, pp.1-12.
https://search.emarefa.net/detail/BIM-1172893
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1172893
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر