![](/images/graphics-bg.png)
Changes in miRNA Gene Expression during Wound Repair in Differentiated Normal Human Bronchial Epithelium
المؤلفون المشاركون
Szczepankiewicz, Aleksandra
Dmitrzak-Weglarz, Monika
Langwiński, Wojciech
Narożna, Beata
Jackson, Claire
Lackie, Peter M.
Stachowiak, Zuzanna
Holloway, John W.
المصدر
International Journal of Genomics
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-09-05
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Purpose.
Airway epithelium acts as a protective barrier against the particles from the inhaled air.
Damage to the epithelium may result in loss of the barrier function.
Epithelial repair in response to injury requires complex mechanisms, such as microRNA, small noncoding molecules, to regulate the processes involved in wound repair.
We aimed to establish if the microRNA gene expression profile is altered during the airway epithelial repair in differentiated cells.
Methods.
miRNA gene expression profile during the wound closure of differentiated normal human bronchial epithelium (NHBE) from one donor was analysed using quantitative real-time PCR.
We have analysed the expression of 754 genes at five time points during a 48-hour period of epithelium repair using TaqMan Low Density Array.
Results.
We found out that 233 miRNA genes were expressed in normal human bronchial epithelium.
Twenty miRNAs were differentially expressed during the wound repair process, but only one (miR-455-3p) showed significance after FDR adjustment (p=0.02).
Using STEM, we have identified two clusters of several miRNA genes with similar expression profile.
Pathway enrichment analysis showed several significant signaling pathways altered during repair, mainly involved in cell cycle regulation, proliferation, migration, adhesion, and transcription regulation.
Conclusions.
miRNA expression profile is altered during airway epithelial repair of differentiated cells from one donor in response to mechanical injury in vitro, suggesting their potential role in wound repair.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Narożna, Beata& Langwiński, Wojciech& Jackson, Claire& Lackie, Peter M.& Holloway, John W.& Stachowiak, Zuzanna…[et al.]. 2018. Changes in miRNA Gene Expression during Wound Repair in Differentiated Normal Human Bronchial Epithelium. International Journal of Genomics،Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1172907
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Narożna, Beata…[et al.]. Changes in miRNA Gene Expression during Wound Repair in Differentiated Normal Human Bronchial Epithelium. International Journal of Genomics No. 2018 (2018), pp.1-8.
https://search.emarefa.net/detail/BIM-1172907
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Narożna, Beata& Langwiński, Wojciech& Jackson, Claire& Lackie, Peter M.& Holloway, John W.& Stachowiak, Zuzanna…[et al.]. Changes in miRNA Gene Expression during Wound Repair in Differentiated Normal Human Bronchial Epithelium. International Journal of Genomics. 2018. Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1172907
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1172907
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
![](/images/ebook-kashef.png)
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
![](/images/kashef-image.png)