Different Contributions of Dyslipidemia and Obesity to the Natural History of Type 2 Diabetes: 3-Year Cohort Study in China
المؤلفون المشاركون
Ning, Guang
Liu, Lu
Zhao, Meng
Zheng, Dongmei
Guan, Qingbo
Zhang, Haiqing
Zhao, Jiajun
Guan, Xiaoling
Yuan, Zhongshang
Li, Qiu
Xu, Jin
Gao, Ling
Zhang, Xu
المصدر
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-03-04
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Aim.
It is known that different stages of type 2 diabetes represent distinct pathophysiological changes, but how the spectrum of risk factors varies at different stages is not yet clarified.
Hence, the aim of this study was to compare the effect of different metabolic variables on the natural history of type 2 diabetes.
Methods.
A total of 5,213 nondiabetic (normal glucose tolerance (NGT) and prediabetes) Chinese older than 40 years participated this prospective cohort study, and 4,577 completed the 3-year follow-up.
Glycemic status was determined by standard oral glucose tolerance test both at enrollment and follow-up visit.
Predictors for conversion in glycemic status were studied in a corresponding subcohort using the multiple logistic regression analysis.
Results.
The incidence of prediabetes and diabetes of the cohort was 93.6 and 42.2 per 1,000 person-years, respectively.
After a 3-year follow-up, 33.1% of prediabetes patients regressed to NGT.
The predictive weight of body mass index (BMI), serum triglyceride, total cholesterol, and systolic blood pressure in different paths of conversions among diabetes, prediabetes, and NGT differed.
Specifically, BMI was the strongest predictor for regression from prediabetes to NGT, while triglyceride was most prominent for onset of diabetes.
One SD increase in serum triglyceride was associated with a 1.29- (95% CI 1.10–1.52; P=0.002) or 1.12- (95% CI 1.01–1.27; P=0.039) fold higher risk of diabetes for individuals with NGT or prediabetes, respectively.
Conclusion.
Risk factors for different stages of diabetes differed, suggesting personalized preventive strategies for individuals with different basal glycemic statuses.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Liu, Lu& Guan, Xiaoling& Yuan, Zhongshang& Zhao, Meng& Li, Qiu& Zhang, Xu…[et al.]. 2019. Different Contributions of Dyslipidemia and Obesity to the Natural History of Type 2 Diabetes: 3-Year Cohort Study in China. Journal of Diabetes Research،Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1172928
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Liu, Lu…[et al.]. Different Contributions of Dyslipidemia and Obesity to the Natural History of Type 2 Diabetes: 3-Year Cohort Study in China. Journal of Diabetes Research No. 2019 (2019), pp.1-10.
https://search.emarefa.net/detail/BIM-1172928
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Liu, Lu& Guan, Xiaoling& Yuan, Zhongshang& Zhao, Meng& Li, Qiu& Zhang, Xu…[et al.]. Different Contributions of Dyslipidemia and Obesity to the Natural History of Type 2 Diabetes: 3-Year Cohort Study in China. Journal of Diabetes Research. 2019. Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1172928
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1172928
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر