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Nonredundant, Highly Connected MicroRNAs Control Functionality in Breast Cancer Networks
المؤلفون المشاركون
Anda-Jáuregui, Guillermo de
Espinal-Enríquez, Jesús
Drago-García, Diana
Hernández-Lemus, Enrique
المصدر
International Journal of Genomics
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-05-29
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Alterations to transcriptional regulation are an important factor in breast cancer.
Noncoding RNA, such as microRNA (miR), have very influential roles in the transcriptional regulation of genes.
Transcriptional regulation can be successfully modeled and analyzed using complex network theory.
Particularly, interactions between two distinct classes of biological elements, such as miR and genes, can be approached through the bipartite network formalism.
Based on bipartite network properties, it is possible to identify highly influential miRs in the network, such as those that have a large number of connections indicating regulation of a large set of genes.
Some miRs in a network are nonredundant, which indicates that they are solely responsible of the regulation of a particular set of genes, which in turn may be associated to a particular biological process.
We hypothesize that highly influential, nonredundant miRs, which we call Commodore miRs (Cdre-miRs), have an important role on the control of biological functions through transcriptional networks.
In this work, we analyze the regulation of gene expression by miRs in healthy and cancerous breast tissue using bipartite miR-gene networks inferred from the Cancer Genome Atlas (TCGA) expression data.
We observe differences in the degree, clustering coefficient and redundancy distributions for miRs and genes in the network, indicating differences in the way that these elements interact with each other.
Furthermore, we identify a small set of five Cdre-miRs in the breast cancer network: miR-190b, miR-let7i, miR-292-b, miR-511, and miR-141.
The neighborhood of genes controlled by each of these miRs is involved in particular biological functions such as dynein structure-associated processes, immune response, angiogenesis, cytokine activity, and cell motility.
We propose that these Cdre-miRs are important control elements of biological functions deregulated in breast cancer.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Anda-Jáuregui, Guillermo de& Espinal-Enríquez, Jesús& Drago-García, Diana& Hernández-Lemus, Enrique. 2018. Nonredundant, Highly Connected MicroRNAs Control Functionality in Breast Cancer Networks. International Journal of Genomics،Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1172929
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Anda-Jáuregui, Guillermo de…[et al.]. Nonredundant, Highly Connected MicroRNAs Control Functionality in Breast Cancer Networks. International Journal of Genomics No. 2018 (2018), pp.1-10.
https://search.emarefa.net/detail/BIM-1172929
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Anda-Jáuregui, Guillermo de& Espinal-Enríquez, Jesús& Drago-García, Diana& Hernández-Lemus, Enrique. Nonredundant, Highly Connected MicroRNAs Control Functionality in Breast Cancer Networks. International Journal of Genomics. 2018. Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1172929
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1172929
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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