Helicobacter pylori Infection as a Risk Factor for Hepatocellular Carcinoma: A Case-Control Study in Ethiopia
المؤلفون المشاركون
Galle, Peter R.
Desalegn, Hailemichael
Fisseha, Henok
Getinet, Tewodros
Tekle, Fisseha
المصدر
International Journal of Hepatology
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-12-02
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Background and Aims.
Hepatocellular carcinoma is a major cause of cancer death worldwide, accounting for over half a million deaths per year.
Its incidence varies with geographic locations and the type of etiologic factors.
In Ethiopia, unidentified causes of liver disease are of sizeable proportion.
Recent studies have shown an association of H.
pylori infection with different spectrums of chronic liver disease.
This study was conducted at St.
Paul’s Hospital Millennium Medical College in Ethiopia and assesses liver cancer and the association with H.
pylori infection.
Method.
A prospective case-control study conducted on patients with chronic liver disease presenting with a suspicious liver lesion and diagnosed to have HCC in the Gastrointestinal (GI) Clinic of St.
Paul’s Hospital MMC from Dec 30, 2016, to Nov 1, 2017 G.C.
Descriptive surveys on clinical history and physical examination and laboratory profiles were obtained, and the clinical course of the patients including the type of treatment was followed prospectively.
Control cases were taken from adult patients without evidence of liver disease in the internal medicine clinic coming for routine evaluation.
After collection data were analyzed using SPSS version 23 and associations were assessed using chi-square test.
Binary logistic regression was used to assess the association of HCC with different variables and H.
pylori infection.
All variables with p-value <0.05 were considered as statistically significant.
Results.
One hundred twenty patients were analyzed with equal representation of cases and controls.
The majority of patients with HCC were male with a mean age of 36 years.
Older age adjusted Odds Ratio (AOR) (95%CI, p-value) 1.07(1.03-1.09, <0.001), viral hepatitis B (AOR) (95%CI, p-value) 6.19 (1.92-19.93, 0.002), and H.
pylori infection (AOR) (95%CI, p-value) 5.22 (2.04–13.31, <0.001) were statistically significantly associated with HCC.
Conclusion.
H.
pylori infection is associated with HCC in this case-control study.
This study supports the emerging evidence of H.
pylori association with other extra-gastric manifestations.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Desalegn, Hailemichael& Fisseha, Henok& Getinet, Tewodros& Tekle, Fisseha& Galle, Peter R.. 2018. Helicobacter pylori Infection as a Risk Factor for Hepatocellular Carcinoma: A Case-Control Study in Ethiopia. International Journal of Hepatology،Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1173047
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Desalegn, Hailemichael…[et al.]. Helicobacter pylori Infection as a Risk Factor for Hepatocellular Carcinoma: A Case-Control Study in Ethiopia. International Journal of Hepatology No. 2018 (2018), pp.1-7.
https://search.emarefa.net/detail/BIM-1173047
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Desalegn, Hailemichael& Fisseha, Henok& Getinet, Tewodros& Tekle, Fisseha& Galle, Peter R.. Helicobacter pylori Infection as a Risk Factor for Hepatocellular Carcinoma: A Case-Control Study in Ethiopia. International Journal of Hepatology. 2018. Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1173047
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1173047
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر