Prevalence and Determinants of Significant Liver Fibrosis by Vibration-Controlled Transient Elastography in Thai Chronic Hepatitis B Patients
المؤلفون المشاركون
Sirinawasatien, Apichet
Techasirioangkun, Thanaya
Thongsri, Siriporn
المصدر
International Journal of Hepatology
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-10-02
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Aims.
To describe the prevalence of significant liver fibrosis by ultrasound-based vibration-controlled transient elastography (VCTE; FibroScan®) and to identify the determinants of significant liver fibrosis in Thai chronic hepatitis B patients.
Methods.
A cross-sectional study of consecutive chronic hepatitis B patients performed VCTE and followed up at Rajavithi Hospital, Bangkok, Thailand, was conducted between 1 January, 2013, and 31 December, 2016.
Liver fibrosis was defined as minimal (METAVIR F0-1) by VCTE < 7.2 kPa and significant (METAVIR F2-4) by VCTE ≥ 7.2 kPa.
VCTE assessments and medical records were retrospectively reviewed.
The prevalence and determinants of significant liver fibrosis were analyzed.
Results.
A total of 206 eligible patients were included; 120 patients (58.3%) were female.
The mean age was 50 years (SD 12.4 years), and 32.5% had a body mass index ≥ 25.
The prevalences of minimal (F 0-1) and significant fibrosis (F2-4) were 74.3% and 25.7%, respectively.
The prevalence of hepatitis B e antigen negative (HBeAg -ve) was 83%.
The median serum hepatitis B virus viral load was 4,340 IU/mL (range 20-271,883,036).
Significant determinants of significant fibrosis (F2-4) were male gender (aOR 3.24 [95%CI: 1.36-7.72]) and high aspartate transaminase (AST) level (aOR 5.71 [95%CI: 2.03-16.04]).
Conclusion.
Around one-quarter of the Thai patients with chronic viral hepatitis B had significant liver disease defined by VCTE, requiring further evaluation for specific treatment for hepatitis B virus.
Determinants of significant liver fibrosis were male gender and high AST level.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Sirinawasatien, Apichet& Techasirioangkun, Thanaya& Thongsri, Siriporn. 2018. Prevalence and Determinants of Significant Liver Fibrosis by Vibration-Controlled Transient Elastography in Thai Chronic Hepatitis B Patients. International Journal of Hepatology،Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1173057
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Sirinawasatien, Apichet…[et al.]. Prevalence and Determinants of Significant Liver Fibrosis by Vibration-Controlled Transient Elastography in Thai Chronic Hepatitis B Patients. International Journal of Hepatology No. 2018 (2018), pp.1-7.
https://search.emarefa.net/detail/BIM-1173057
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Sirinawasatien, Apichet& Techasirioangkun, Thanaya& Thongsri, Siriporn. Prevalence and Determinants of Significant Liver Fibrosis by Vibration-Controlled Transient Elastography in Thai Chronic Hepatitis B Patients. International Journal of Hepatology. 2018. Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1173057
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1173057
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر