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Sanbai Melon Seed Oil Exerts Its Protective Effects in a Diabetes Mellitus Model via the AktGSK-3βNrf2 Pathway
المؤلفون المشاركون
Wang, Si-Wang
He, Qiaoyan
Wang, Fang
Zhang, Ya
Li, Jie
Xi, Yuanhang
Liu, Wenzhe
Jia, Min
Zhao, Hongsheng
المصدر
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-09-12
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Traditional Chinese medicine (TCM) plays an important role in the treatment of type 2 diabetes mellitus (T2DM).
However, the lack of adequate and scientifically rigorous evidence has limited its application in this disorder.
Sanbai melon seed oil (SMSO) is used in folk medicine to treat DM; however, only few literature reports exist regarding its mechanism.
Herein, we aimed to confirm the antidiabetic activity of SMSO in a T2DM model and further elucidate its possible mechanisms.
The T2DM rat model was induced by high-fat and sugar diet and streptozocin (STZ, 40 mg/kg).
SMSO was administered at doses of 0.7 g/kg, 1.4 g/kg, and 2.8 g/kg.
Several biochemical parameters and antioxidant protein levels were measured to evaluate the hyperglycemic and antioxidant activities of SMSO.
Western blotting was performed to determine its potential mechanism.
Based on the results, SMSO treatment significantly reduced blood glucose levels, increased plasma insulin, and repaired islet tissue injury in diabetic rats (P<0.05).
To add, it markedly reduced MDA levels and increased that of catalase (CAT), superoxide dismutase (SOD), and glutathione peroxidase (GSH-Px).
Western blot results showed that SMSO induced n-Nrf2 and HO-1 expression and Akt and GSK-3β phosphorylation in a dose-dependent manner.
Further studies showed that LY294002, aPI3K inhibitor, abolished the effects of SMSO on GSK-3β phosphorylation and Nrf2 nuclear translocation as well as the protective effects on pancreatic β cells.
Together, these results suggest that SMSO regulates the Akt/GSK-3β/Nrf2 pathway and induces the expression of antioxidant proteins to impede oxidative stress in rats with T2DM.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wang, Fang& Xi, Yuanhang& Liu, Wenzhe& Li, Jie& Zhang, Ya& Jia, Min…[et al.]. 2019. Sanbai Melon Seed Oil Exerts Its Protective Effects in a Diabetes Mellitus Model via the AktGSK-3βNrf2 Pathway. Journal of Diabetes Research،Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1173066
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wang, Fang…[et al.]. Sanbai Melon Seed Oil Exerts Its Protective Effects in a Diabetes Mellitus Model via the AktGSK-3βNrf2 Pathway. Journal of Diabetes Research No. 2019 (2019), pp.1-11.
https://search.emarefa.net/detail/BIM-1173066
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wang, Fang& Xi, Yuanhang& Liu, Wenzhe& Li, Jie& Zhang, Ya& Jia, Min…[et al.]. Sanbai Melon Seed Oil Exerts Its Protective Effects in a Diabetes Mellitus Model via the AktGSK-3βNrf2 Pathway. Journal of Diabetes Research. 2019. Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1173066
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1173066
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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