Relationship between Serum Cytokeratin-18, Control Attenuation Parameter, NAFLD Fibrosis Score, and Liver Steatosis in Nonalcoholic Fatty Liver Disease
المؤلفون المشاركون
Kosasih, Sumitro
Raja Ali, Raja Affendi
Zhi Qin, Wong
Abdul Rani, Rafiz
Abd Hamid, Nazefah
Chai Soon, Ngiu
Azhar Shah, Shamsul
Yaakob, Yazmin
المصدر
International Journal of Hepatology
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-09-27
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Backgrounds.
The aim of this study was to appraise the relationship between serum fragmented cytokeratin-18(CK-18), controlled attenuation parameter (CAP), and liver steatosis assessed by ultrasound (US) in nonalcoholic fatty liver disease (NAFLD) patients.
Methods.
Patients who underwent abdominal US were recruited, followed with measurement of CAP using Fibroscan® and serum fragmented CK-18 using enzyme-linked immunosorbent assay.
The degree of liver steatosis assessed by US was categorized into mild (S1), moderate (S2), and severe (S3).
Results.
A total of 109 patients were included in our study.
CAP and fragmented CK-18 level were significantly correlated with liver steatosis grade with rs = 0.56 and 0.68, p=0.001, respectively.
NAFLD Fibrosis Score was poorly correlated with liver steatosis grade (rs=-0.096, p=0.318).
Using fragmented CK-18 level, area under receiver operating characteristic (AUROC) curves for S≥2 and S≥3 were excellent (0.82 and 0.84, respectively).
Using CAP, AUROC curves for detection of S≥2 and S≥3 were good (0.76, 0.77, respectively).
We also proposed cut-off value of CAP to detect S≥2 and S≥3 to be 263 and 319db/m, respectively, and fragmented CK-18 level to detect S≥2 and S≥3 (194 and 294 U/L, respectively).
Conclusions.
Both the fragmented CK-18 level and the CAP, but not NAFLD Fibrosis Score, were well correlated with hepatic steatosis grade as assessed by US.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Kosasih, Sumitro& Zhi Qin, Wong& Abdul Rani, Rafiz& Abd Hamid, Nazefah& Chai Soon, Ngiu& Azhar Shah, Shamsul…[et al.]. 2018. Relationship between Serum Cytokeratin-18, Control Attenuation Parameter, NAFLD Fibrosis Score, and Liver Steatosis in Nonalcoholic Fatty Liver Disease. International Journal of Hepatology،Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1173068
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Kosasih, Sumitro…[et al.]. Relationship between Serum Cytokeratin-18, Control Attenuation Parameter, NAFLD Fibrosis Score, and Liver Steatosis in Nonalcoholic Fatty Liver Disease. International Journal of Hepatology No. 2018 (2018), pp.1-9.
https://search.emarefa.net/detail/BIM-1173068
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Kosasih, Sumitro& Zhi Qin, Wong& Abdul Rani, Rafiz& Abd Hamid, Nazefah& Chai Soon, Ngiu& Azhar Shah, Shamsul…[et al.]. Relationship between Serum Cytokeratin-18, Control Attenuation Parameter, NAFLD Fibrosis Score, and Liver Steatosis in Nonalcoholic Fatty Liver Disease. International Journal of Hepatology. 2018. Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1173068
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1173068
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر