Serum Carnosinase-1 and Albuminuria Rather than the CNDP1 Genotype Correlate with Urinary Carnosinase-1 in Diabetic and Nondiabetic Patients with Chronic Kidney Disease
المؤلفون المشاركون
Yard, Benito A.
Bakker, Stephan J. L.
van den Born, Jaap
Hauske, Sibylle J.
Rodriguez-Niño, Angelica
Herold, Anna
Qiu, Jiedong
Krämer, Bernhard K.
المصدر
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-12-26
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Background.
Carnosinase-1 (CN-1) can be detected in 24 h urine of healthy individuals and patients with type 2 diabetes (T2DM).
We aimed to assess whether urinary CN-1 is also reliably measured in spot urine and investigated its association with renal function and the albumin/creatinine ratio (ACR).
We also assessed associations between the CNDP1 (CTG)n genotype and CN-1 concentrations in serum and urine.
Methods.
Patients with T2DM (n=85) and nondiabetic patients with chronic kidney disease (CKD) (n=26) stratified by albuminuria (ACR≤300 mg/g or ACR>300 mg/g) recruited from the nephrology clinic and healthy subjects (n=24) were studied.
Results.
Urinary CN-1 was more frequently detected and displayed higher concentrations in patients with ACR>300 mg/g as compared to those with ACR≤300 mg/g irrespective of the baseline disease (T2DM: 554 ng/ml [IQR 212-934 ng/ml] vs.
31 ng/ml [IQR 31-63 ng/ml] (p<0.0001) and nondiabetic CKD: 197 ng/ml [IQR 112-739] vs.
31 ng/ml [IQR 31-226 ng/ml] (p=0.015)).
A positive correlation between urinary CN-1 and ACR was found (r=0.68, p<0.0001).
Multivariate linear regression analysis revealed that ACR and serum CN-1 concentrations but not eGFR or the CNDP1 genotype are independent predictors of urinary CN-1, explaining 47% of variation of urinary CN-1 concentrations (R2=0.47, p<0.0001).
Conclusion.
These results confirm and extend previous findings on urinary CN-1 concentrations, suggesting that assessment of CN-1 in spot urine is as reliable as in 24 h urine and may indicate that urinary CN-1 in macroalbuminuric patients is primarily serum-derived and not locally produced.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Rodriguez-Niño, Angelica& Hauske, Sibylle J.& Herold, Anna& Qiu, Jiedong& van den Born, Jaap& Bakker, Stephan J. L.…[et al.]. 2019. Serum Carnosinase-1 and Albuminuria Rather than the CNDP1 Genotype Correlate with Urinary Carnosinase-1 in Diabetic and Nondiabetic Patients with Chronic Kidney Disease. Journal of Diabetes Research،Vol. 2019, no. 2019, pp.1-12.
https://search.emarefa.net/detail/BIM-1173149
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Rodriguez-Niño, Angelica…[et al.]. Serum Carnosinase-1 and Albuminuria Rather than the CNDP1 Genotype Correlate with Urinary Carnosinase-1 in Diabetic and Nondiabetic Patients with Chronic Kidney Disease. Journal of Diabetes Research No. 2019 (2019), pp.1-12.
https://search.emarefa.net/detail/BIM-1173149
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Rodriguez-Niño, Angelica& Hauske, Sibylle J.& Herold, Anna& Qiu, Jiedong& van den Born, Jaap& Bakker, Stephan J. L.…[et al.]. Serum Carnosinase-1 and Albuminuria Rather than the CNDP1 Genotype Correlate with Urinary Carnosinase-1 in Diabetic and Nondiabetic Patients with Chronic Kidney Disease. Journal of Diabetes Research. 2019. Vol. 2019, no. 2019, pp.1-12.
https://search.emarefa.net/detail/BIM-1173149
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1173149
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر