Plasma Levels of Free Fatty Acids in Women with Gestational Diabetes and Its Intrinsic and Extrinsic Determinants: Systematic Review and Meta-Analysis
المؤلفون المشاركون
Villafan-Bernal, Jose Rafael
Acevedo-Alba, Mariana
Reyes-Pavon, Rodrigo
Diaz-Parra, Guillermo Andres
Lip-Sosa, Diana Lucia
Vazquez-Delfin, Hilda Imelda
Hernandez-Muñoz, Martha
Bravo-Aguirre, Daniel Ely
Figueras, Francesc
Martinez-Portilla, Raigam Jafet
المصدر
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-08-18
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
Background.
Free fatty acids, also known as nonesterified fatty acids, are proinflammatory molecules that induce insulin resistance in nonpregnant individuals.
Nevertheless, the concentration of these molecules has not been systematically addressed in pregnant women.
Objective.
This meta-analysis is aimed at evaluating the difference in free fatty acid plasma levels between women with gestational diabetes and healthy pregnant controls and their intrinsic and extrinsic determinants.
Methods.
We performed a systematic search to find relevant studies published in English and Spanish using PubMed, SCOPUS, and ISI Web of Knowledge.
We included observational studies measuring the mean plasma levels of free fatty acids among gestational diabetes and healthy pregnant women, with at least ten subjects being analyzed in each group.
The standardized mean difference (SMD) by random effects modeling was used.
Heterogeneity was assessed using Cochran’s Q, H, and I2 statistics.
Results.
Among the 290 identified studies, twelve were selected for analysis.
A total of 2426 women were included, from which 21% were diagnosed as having gestational diabetes.
There were significantly higher levels of free fatty acids among women with gestational diabetes (SMD: 0.86; 0.54-1.18; p<0.001) when compared to healthy pregnant controls and between-study heterogeneity (I2=91%).
The metaregression analysis showed that the gestational age at inclusion was the only cofactor influencing the mean levels of free fatty acids, indicating a trend towards lower plasma levels of free fatty acids later in gestation (estimate: -0.074; -0.143 to -0.004; p=0.036).
No significant publication bias was found nor a trend towards greater results in small studies.
Conclusions.
Women with gestational diabetes have higher levels of free fatty acids when compared to healthy pregnant controls.
More investigation is needed to assess the potential role of free fatty acids in the prediction of gestational diabetes earlier in pregnancy.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Villafan-Bernal, Jose Rafael& Acevedo-Alba, Mariana& Reyes-Pavon, Rodrigo& Diaz-Parra, Guillermo Andres& Lip-Sosa, Diana Lucia& Vazquez-Delfin, Hilda Imelda…[et al.]. 2019. Plasma Levels of Free Fatty Acids in Women with Gestational Diabetes and Its Intrinsic and Extrinsic Determinants: Systematic Review and Meta-Analysis. Journal of Diabetes Research،Vol. 2019, no. 2019, pp.1-13.
https://search.emarefa.net/detail/BIM-1173162
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Villafan-Bernal, Jose Rafael…[et al.]. Plasma Levels of Free Fatty Acids in Women with Gestational Diabetes and Its Intrinsic and Extrinsic Determinants: Systematic Review and Meta-Analysis. Journal of Diabetes Research No. 2019 (2019), pp.1-13.
https://search.emarefa.net/detail/BIM-1173162
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Villafan-Bernal, Jose Rafael& Acevedo-Alba, Mariana& Reyes-Pavon, Rodrigo& Diaz-Parra, Guillermo Andres& Lip-Sosa, Diana Lucia& Vazquez-Delfin, Hilda Imelda…[et al.]. Plasma Levels of Free Fatty Acids in Women with Gestational Diabetes and Its Intrinsic and Extrinsic Determinants: Systematic Review and Meta-Analysis. Journal of Diabetes Research. 2019. Vol. 2019, no. 2019, pp.1-13.
https://search.emarefa.net/detail/BIM-1173162
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1173162
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر