Potential Pitfalls of the Humanized Mice in Modeling Sepsis
المؤلفون المشاركون
Laudanski, Krzysztof
Stentz, Michael
DiMeglio, Matthew
Furey, William
Steinberg, Toby
Patel, Arpit
المصدر
International Journal of Inflammation
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-09-02
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Humanized mice are a state-of-the-art tool used to study several diseases, helping to close the gap between mice and human immunology.
This review focuses on the potential obstacles in the analysis of immune system performance between humans and humanized mice in the context of severe acute inflammation as seen in sepsis or other critical care illnesses.
The extent to which the reconstituted human immune system in mice adequately compares to the performance of the human immune system in human hosts is still an evolving question.
Although certain viral and protozoan infections can be replicated in humanized mice, whether a highly complex and dynamic systemic inflammation like sepsis can be accurately represented by current humanized mouse models in a clinically translatable manner is unclear.
Humanized mice are xenotransplant animals in the most general terms.
Several organs (e.g., bone marrow mesenchymal cells, endothelium) cannot interact with the grafted human leukocytes effectively due to species specificity.
Also the interaction between mice gut flora and the human immune system may be paradoxical.
Often, grafting is performed utilizing an identical batch of stem cells in highly inbred animals which fails to account for human heterogeneity.
Limiting factors include the substantial cost and restricting supply of animals.
Finally, humanized mice offer an opportunity to gain knowledge of human-like conditions, requiring careful data interpretation just as in nonhumanized animals.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Laudanski, Krzysztof& Stentz, Michael& DiMeglio, Matthew& Furey, William& Steinberg, Toby& Patel, Arpit. 2018. Potential Pitfalls of the Humanized Mice in Modeling Sepsis. International Journal of Inflammation،Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1173255
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Laudanski, Krzysztof…[et al.]. Potential Pitfalls of the Humanized Mice in Modeling Sepsis. International Journal of Inflammation No. 2018 (2018), pp.1-9.
https://search.emarefa.net/detail/BIM-1173255
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Laudanski, Krzysztof& Stentz, Michael& DiMeglio, Matthew& Furey, William& Steinberg, Toby& Patel, Arpit. Potential Pitfalls of the Humanized Mice in Modeling Sepsis. International Journal of Inflammation. 2018. Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1173255
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1173255
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر