A CFA-Induced Model of Inflammatory Skin Disease in Miniature Swine
المؤلفون المشاركون
Navarro-Alvarez, Nalú
Gonçalves, Beatriz M. M.
Andrews, Alec R.
Huang, Christene A.
Sachs, David H.
المصدر
International Journal of Inflammation
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-06-24
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Similarities between porcine and human skin make the pig an ideal model for preclinical studies of cutaneous inflammation and wound healing.
Complete Freund’s adjuvant (CFA) has been used to induce inflammation and to study inflammatory pain in several animal models.
Here, we evaluated the inflammation caused by CFA injected in different layers of skin and subcutaneous (SC) tissue in a large-animal model.
The degree of inflammation was evaluated at early and late time points by visual inspection and histopathologic analysis.
In addition, the side effects of CFA injections were evaluated based on clinical findings, behavioral changes, physiologic state, and (histo)pathologic lesions.
Pigs were injected with CFA at the back of the neck’s skin at different depths.
All animals showed histologic signs of inflammation at the injection site.
Animals injected SC did not show any signs of pain or distress (loss of appetite, abnormal behavior) and did not require pain medication.
Inflammation was followed by measuring the area of induration beneath the skin.
Animals injected into the dermis and/or epidermis demonstrated a severe inflammatory response on the skin surface with massive swelling, redness within 12hrs of CFA injection, and severe skin necrosis within a week, preventing accurate induration measurements.
In contrast to animals injected SC, animals receiving intradermal and/or intraepidermal injection of CFA showed signs of distress requiring pain medication.
Conclusion.
SC injection of CFA in swine induces an inflammatory response that can be measured accurately by induration without causing unnecessary discomfort, providing a useful preclinical large-animal model of inflammatory skin disease.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Navarro-Alvarez, Nalú& Gonçalves, Beatriz M. M.& Andrews, Alec R.& Sachs, David H.& Huang, Christene A.. 2018. A CFA-Induced Model of Inflammatory Skin Disease in Miniature Swine. International Journal of Inflammation،Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1173257
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Navarro-Alvarez, Nalú…[et al.]. A CFA-Induced Model of Inflammatory Skin Disease in Miniature Swine. International Journal of Inflammation No. 2018 (2018), pp.1-8.
https://search.emarefa.net/detail/BIM-1173257
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Navarro-Alvarez, Nalú& Gonçalves, Beatriz M. M.& Andrews, Alec R.& Sachs, David H.& Huang, Christene A.. A CFA-Induced Model of Inflammatory Skin Disease in Miniature Swine. International Journal of Inflammation. 2018. Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1173257
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1173257
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر