Combined Oral Contraceptive Effects on Low-Grade Chronic Inflammatory Mediators in Women with Polycystic Ovary Syndrome: A Systematic Review and Meta-Analysis
المؤلفون المشاركون
de Medeiros, Sebastião Freitas
Medeiros, Matheus Antônio Souto de
Santos, Nayara de Souza
Barbosa, Bruna Barcelo
Yamamoto, Márcia Marly Winck
المصدر
International Journal of Inflammation
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-11-25
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
Polycystic ovary syndrome is associated with dyslipidemia, dysglycemia, metabolic syndrome, and low-grade chronic inflammation, which increase the risks for cardiovascular disease.
Combined oral contraceptives may affect the mediators of low-grade chronic inflammation with potential additive risk in PCOS patients.
This meta-analysis investigates the impact of oral contraceptive on markers of chronic inflammation in PCOS patients.
Pubmed, Scopus, and Cochrane database were used to search studies reporting on this matter in the target population.
Twenty seven studies were selected, including a total of 838 women.
The data were expressed as the standardized mean difference.
The random-effects model was used to summarize effect sizes.
Heterogeneity was examined using Cochran’s test (Q) and I2 statistics.
Most of the preparations increased C-reactive protein (CRP) in PCOS patients (p >0.001).
The increase in homocysteine levels was not significant (p >0.05).
Follistatin significantly increased with pills containing cyproterone acetate (p= 0.008).
Interleukin-6 changes were inconsistent and plasminogen activator inhibitor-1 decreased with pills containing desogestrel, norgestimate, and drospirenone.
Collectively, the results of this review indicate that oral contraceptives modify most inflammatory markers of PCOS patients.
However, the clinical implications are not clear yet and future studies must consider longer follow-up and the inclusion of objective clinical parameters.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
de Medeiros, Sebastião Freitas& Medeiros, Matheus Antônio Souto de& Santos, Nayara de Souza& Barbosa, Bruna Barcelo& Yamamoto, Márcia Marly Winck. 2018. Combined Oral Contraceptive Effects on Low-Grade Chronic Inflammatory Mediators in Women with Polycystic Ovary Syndrome: A Systematic Review and Meta-Analysis. International Journal of Inflammation،Vol. 2018, no. 2018, pp.1-13.
https://search.emarefa.net/detail/BIM-1173266
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
de Medeiros, Sebastião Freitas…[et al.]. Combined Oral Contraceptive Effects on Low-Grade Chronic Inflammatory Mediators in Women with Polycystic Ovary Syndrome: A Systematic Review and Meta-Analysis. International Journal of Inflammation No. 2018 (2018), pp.1-13.
https://search.emarefa.net/detail/BIM-1173266
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
de Medeiros, Sebastião Freitas& Medeiros, Matheus Antônio Souto de& Santos, Nayara de Souza& Barbosa, Bruna Barcelo& Yamamoto, Márcia Marly Winck. Combined Oral Contraceptive Effects on Low-Grade Chronic Inflammatory Mediators in Women with Polycystic Ovary Syndrome: A Systematic Review and Meta-Analysis. International Journal of Inflammation. 2018. Vol. 2018, no. 2018, pp.1-13.
https://search.emarefa.net/detail/BIM-1173266
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1173266
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر