Genetic Variants Flanking the FGF21 Gene Were Associated with Renal Function in Chinese Patients with Type 2 Diabetes
المؤلفون المشاركون
Jia, Weiping
Yu, Weihui
Zhu, Hong
Chen, Xiong
Gu, Xuejiang
Zhang, Xingxing
Shen, Feixia
Hu, Cheng
المصدر
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-05-07
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Aims.
Fibroblast growth factor 21 (FGF21) is closely linked with metabolic disorders including diabetes.
Evidences suggested that FGF21 may play a protective role against diabetic kidney disease (DKD).
However, the relationship between genetic variants in the FGF21 gene region and DKD remains unknown.
In our study, we aimed to investigate the association of genetic variations in this gene region with DKD and DKD-related clinical traits.
Materials and Methods.
We recruited 1340 Han Chinese participants with type 2 diabetes, including 596 DKD patients and 744 patients who was diagnosed with diabetes for more than 5 years but did not progress to DKD.
Three single-nucleotide polymorphisms were selected (rs2071699, rs838136, and rs499765) and genotyped.
The association between these SNPs and DKD as well as DKD-related quantitative traits was analyzed.
Results.
We did not find any significant association between these SNPs and susceptibility to DKD in the present study.
However, a significant association with estimated glomerular filtration rate (eGFR) was detected: in the non-DKD group, rs838136 was significantly associated with eGFR under an additive model (β=0.013±0.006, P=0.0295, β was calculated for log10eGFR) as well as a recessive model (P=0.0385) and rs499765 was associated with eGFR under a dominant model (P=0.0411) and in the DKD group, rs499765 showed a trend toward association with eGFR under an additive model (β=−0.022±0.012, P=0.0820, β was calculated for log10eGFR) and showed a significant association with eGFR under a dominant model (P=0.0182).
Conclusions.
Our findings indicated that genetic variations adjacent to FGF21 were associated with eGFR in Chinese diabetic patients.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Yu, Weihui& Zhu, Hong& Chen, Xiong& Gu, Xuejiang& Zhang, Xingxing& Shen, Feixia…[et al.]. 2019. Genetic Variants Flanking the FGF21 Gene Were Associated with Renal Function in Chinese Patients with Type 2 Diabetes. Journal of Diabetes Research،Vol. 2019, no. 2019, pp.1-6.
https://search.emarefa.net/detail/BIM-1173386
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Yu, Weihui…[et al.]. Genetic Variants Flanking the FGF21 Gene Were Associated with Renal Function in Chinese Patients with Type 2 Diabetes. Journal of Diabetes Research No. 2019 (2019), pp.1-6.
https://search.emarefa.net/detail/BIM-1173386
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Yu, Weihui& Zhu, Hong& Chen, Xiong& Gu, Xuejiang& Zhang, Xingxing& Shen, Feixia…[et al.]. Genetic Variants Flanking the FGF21 Gene Were Associated with Renal Function in Chinese Patients with Type 2 Diabetes. Journal of Diabetes Research. 2019. Vol. 2019, no. 2019, pp.1-6.
https://search.emarefa.net/detail/BIM-1173386
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1173386
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر