Association between Metformin Use and Coronary Artery Calcification in Type 2 Diabetic Patients
المؤلفون المشاركون
Lu, Yi
Wang, Yidong
Weng, Ting
Chen, Zexin
Sun, Xiujuan
Wei, Jia
Cai, Zhejun
Xiang, Meixiang
المصدر
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-05-05
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Objectives.
Type 2 diabetes mellitus (T2DM) is associated with coronary artery calcification (CAC) which is an independent risk factor for cardiovascular events.
Metformin is the first-line antidiabetic medication.
We aimed to investigate the association between metformin use and CAC.
Methods.
We included 369 patients with T2DM in this cross-sectional study.
CAC scores, clinical characteristics, and antidiabetic drug prescription information of the patients were acquired.
Baseline parameters were balanced for metformin and nonmetformin users using the propensity score matching (PSM) strategy.
Results.
Among the 369 subjects who met our inclusion criteria, 288 subjects were included for further analysis after PSM.
Metformin prescription rather than other antidiabetic medications was related to lower CAC scores (OR [95% CI] = 0.55 [0.34–0.90]; P=0.018).
Further multivariable logistic regression analysis demonstrated that metformin was negatively associated with CAC severity (OR [95% CI] = 0.58 [0.34–0.99]; P=0.048), which was independent of age, BMI, eGFR, gender, cigarette smoking, duration of diabetes, hypertension, statin prescription, and number of nonmetformin antidiabetic agents.
A subgroup analysis revealed a significant association between metformin and CAC scores in smokers (OR [95% CI] = 0.38 [0.16–0.93]; P=0.035), but the association was not observed in never-smokers (OR [95% CI] = 0.72 [0.34–1.51]; P=0.383).
Conclusions.
Metformin usage was independently associated with lower CAC scores in T2DM patients.
The negative correlation between CAC scores and metformin was most prominent in patients with a history of cigarette smoking.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Lu, Yi& Wang, Yidong& Weng, Ting& Chen, Zexin& Sun, Xiujuan& Wei, Jia…[et al.]. 2019. Association between Metformin Use and Coronary Artery Calcification in Type 2 Diabetic Patients. Journal of Diabetes Research،Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1173410
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Lu, Yi…[et al.]. Association between Metformin Use and Coronary Artery Calcification in Type 2 Diabetic Patients. Journal of Diabetes Research No. 2019 (2019), pp.1-8.
https://search.emarefa.net/detail/BIM-1173410
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Lu, Yi& Wang, Yidong& Weng, Ting& Chen, Zexin& Sun, Xiujuan& Wei, Jia…[et al.]. Association between Metformin Use and Coronary Artery Calcification in Type 2 Diabetic Patients. Journal of Diabetes Research. 2019. Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1173410
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1173410
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر