Effect of the Interaction between Obstructive Sleep Apnea and Lipoprotein(a) on Insulin Resistance: A Large-Scale Cross-Sectional Study
المؤلفون المشاركون
Li, Xinyi
Yin, Shankai
Zou, Juanjuan
Xu, Huajun
Qian, Yingjun
Zou, Jianyin
Liu, Suru
Meng, Lili
Yi, Hongliang
Guan, Jian
Liu, Yupu
Zhao, Xiaolong
المصدر
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-04-08
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Both obstructive sleep apnea (OSA) and decreased serum lipoprotein(a) (Lp(a)) concentrations are associated with insulin resistance.
However, their interaction effect on insulin resistance has never been investigated.
Therefore, we performed a cross-sectional study on OSA-suspected Chinese Han participants.
Laboratory-based polysomnographic variables, biochemical indicators, anthropometric measurements, and medical history were collected.
Linear regression and binary logistic regression analyses with interaction terms were used to investigate the potential effects of the interaction between the severity of OSA (assessed by the apnea-hypopnea index (AHI)) and Lp(a) concentrations on insulin resistance (assessed by the homeostasis model assessment of insulin resistance (HOMA-IR)), after adjusting for potential confounders including age, gender, body mass index, waist-to-hip circumference ratio, mean arterial pressure, smoking status, drinking status, and lipid profiles.
A total of 4,152 participants were enrolled.
In the OSA-suspected population, AHI positively correlated with insulin resistance and serum Lp(a) concentrations independently and inversely correlated with insulin resistance.
In addition, the interaction analysis showed that the linear association between lgAHI and lgHOMA-IR was much steeper and more significant in subjects with relatively low Lp(a) concentrations, suggesting a significant positive interaction between lgLp(a) and lgAHI on lgHOMA-IR (P=0.013).
Furthermore, the interaction on a multiplicative scale also demonstrated a significant positive interaction (P=0.044).
A stronger association between AHI quartiles and the presence of insulin resistance (defined as HOMA-IR > 3) could be observed for participants within lower Lp(a) quartiles.
In conclusion, a significant positive interaction was observed between OSA and decreased Lp(a) with respect to insulin resistance.
This association might be relevant to the assessment of metabolic or cardiovascular disease risk in OSA patients.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Liu, Yupu& Zou, Juanjuan& Li, Xinyi& Zhao, Xiaolong& Zou, Jianyin& Liu, Suru…[et al.]. 2019. Effect of the Interaction between Obstructive Sleep Apnea and Lipoprotein(a) on Insulin Resistance: A Large-Scale Cross-Sectional Study. Journal of Diabetes Research،Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1173460
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Liu, Yupu…[et al.]. Effect of the Interaction between Obstructive Sleep Apnea and Lipoprotein(a) on Insulin Resistance: A Large-Scale Cross-Sectional Study. Journal of Diabetes Research No. 2019 (2019), pp.1-9.
https://search.emarefa.net/detail/BIM-1173460
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Liu, Yupu& Zou, Juanjuan& Li, Xinyi& Zhao, Xiaolong& Zou, Jianyin& Liu, Suru…[et al.]. Effect of the Interaction between Obstructive Sleep Apnea and Lipoprotein(a) on Insulin Resistance: A Large-Scale Cross-Sectional Study. Journal of Diabetes Research. 2019. Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1173460
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1173460
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر