Vascular Calcification in Chronic Kidney Disease: The Role of Inflammation
المؤلفون المشاركون
Amann, Kerstin U.
Benz, Kerstin
Hilgers, Karl-Friedrich
Daniel, Christoph
المصدر
International Journal of Nephrology
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-08-13
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Cardiovascular complications are extremely frequent in patients with chronic kidney disease (CKD) and death from cardiac causes is the most common cause of death in this particular population.
Cardiovascular disease is approximately 3 times more frequent in patients with CKD than in other known cardiovascular risk groups and cardiovascular mortality is approximately 10-fold more frequent in patients on dialysis compared to the age- and sex-matched segments of the nonrenal population.
Among other structural and functional factors advanced calcification of atherosclerotic plaques as well as of the arterial and venous media has been described as potentially relevant for this high cardiovascular morbidity and mortality.
One potential explanation for this exceedingly high vascular calcification in animal models as well as in patients with CKD increased systemic and most importantly local (micro)inflammation that has been shown to favor the development of calcifying particles by multiple ways.
Of note, local vascular upregulation of proinflammatory and proosteogenic molecules is already present at early stages of CKD and may thus be operative for vascular calcification.
In addition, increased expression of costimulatory molecules and mast cells has also been documented in patients with CKD pointing to a more inflammatory and potentially less stable phenotype of coronary atherosclerotic plaques in CKD.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Benz, Kerstin& Hilgers, Karl-Friedrich& Daniel, Christoph& Amann, Kerstin U.. 2018. Vascular Calcification in Chronic Kidney Disease: The Role of Inflammation. International Journal of Nephrology،Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1173619
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Benz, Kerstin…[et al.]. Vascular Calcification in Chronic Kidney Disease: The Role of Inflammation. International Journal of Nephrology No. 2018 (2018), pp.1-7.
https://search.emarefa.net/detail/BIM-1173619
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Benz, Kerstin& Hilgers, Karl-Friedrich& Daniel, Christoph& Amann, Kerstin U.. Vascular Calcification in Chronic Kidney Disease: The Role of Inflammation. International Journal of Nephrology. 2018. Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1173619
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1173619
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر